Ambroxol

Base Information Edit

Chemical Name:Ambroxol
CAS No.:18683-91-5
Molecular Formula:C₁₃H₁₈Br₂N₂O
Molecular Weight:378.107
Hs Code.:2922199090
European Community (EC) Number:242-500-3
UNII:200168S0CL,QH6ZT6J071
DSSTox Substance ID:DTXSID8022583,DTXSID60860228
Nikkaji Number:J13.659J,J3.274.453B
Wikipedia:Ambroxol
Wikidata:Q221637,Q105124245
NCI Thesaurus Code:C74262
RXCUI:625
Pharos Ligand ID:A3KGNKUQTWCV
ChEMBL ID:CHEMBL153479,CHEMBL1477775
Mol file:18683-91-5.mol

Synonyms:4-(((2-Amino-3,5-dibromophenyl)methyl)amino)cyclohexanol;Abrohexal;AM, Bisolvon;Ambril;Ambro Puren;Ambro-Puren;Ambrobeta;Ambrofur;Ambrohexal;Ambrol?s;Ambrolitic;AMBROPP;AmbroPuren;Ambroten;Ambroxin;Ambroxocompren;Ambroxol;Bisolvon AM;Bromhexine Metabolite VIII;Bronchopront;Bronchowern;Broxol;Contac Husten Trunk;Contac Husten-Trunk;Contac HustenTrunk;Dinobroxol;Duramucal;Ebromin;Expeflen;Expit;Farmabroxol;Flavamed;Frenopect;Gelopol;Hustenl?ser, Pect;Hustenl?ser, Therapin;Larylin Husten L?ser;Larylin Husten-L?ser;Larylin HustenL?ser;Lasolvan;Metabolite VIII, Bromhexine;Mibrox;Motosol;Muco Fips;Muco-Fips;MucoFips;Mucosolvan;Mucotablin;NA 872;NA-872;NA872;P?diamuc;Pect Hustenl?ser;Pulmonal S;Pulmonal, Ringelheimer;Ringelheimer Pulmonal;Sekretovit;stas Hustenl?ser;stas-Hustenl?ser;stasHustenl?ser;Surbronc;Therapin Hustenl?ser

Suppliers and Price of Ambroxol

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Ambroxol
50mg
$ 130.00

Matrix Scientific
trans-4-((2-Amino-3,5-dibromobenzyl)-amino)cyclohexanol hydrochloride 95+%
500mg
$ 20.00

Matrix Scientific
trans-4-((2-Amino-3,5-dibromobenzyl)-amino)cyclohexanol hydrochloride 95+%
250mg
$ 13.00

Matrix Scientific
trans-4-((2-Amino-3,5-dibromobenzyl)-amino)cyclohexanol hydrochloride 95+%
1g
$ 30.00

Crysdot
Ambroxol 98+%
100mg
$ 42.00

ChemScene
Ambroxol 99.83%
100mg
$ 50.00

Cayman Chemical
Ambroxol ≥98%
100mg
$ 93.00

Cayman Chemical
Ambroxol ≥98%
25mg
$ 29.00

Cayman Chemical
Ambroxol ≥98%
50mg
$ 49.00

Biosynth Carbosynth
Ambroxol
500 mg
$ 50.00

Total 142 raw suppliers

Chemical Property of Ambroxol Edit

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Melting Point:233-234 °C
Refractive Index:1.654
Boiling Point:468.647 °C at 760 mmHg
PKA:15.12±0.40(Predicted)
Flash Point:237.23 °C
PSA：58.28000
Density:1.704 g/cm³
LogP:4.15900
Storage Temp.:2-8°C
Solubility.:Soluble in Water.
XLogP3:2.6
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:377.97654
Heavy Atom Count:18
Complexity:259

Purity/Quality:

99% ^*data from raw suppliers

Ambroxol ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn,Xi
Hazard Codes:Xn,Xi
Statements: 22-36/37/38
Safety Statements: 36-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:C1CC(CCC1NCC2=C(C(=CC(=C2)Br)Br)N)O
Recent ClinicalTrials:A Double-blind Randomised, Placebo-controlled Clinical Trial to Test Ambroxol Treatment in ALS
Recent EU Clinical Trials:Ambroxol inhalation for mucus clearance in palliative care patients - a randomized placebo-controlled double-blind pilot study.
Recent NIPH Clinical Trials:Japan-Ambroxol Chaperone Study
Description Ambroxol HCl (18683-91-5) is a radical scavenger with anti-inflammatory activity. Blocks the generation of reactive oxygen species by bronchoalveolar lavage cells, inhibits doxorubicin-induced lipid peroxidation (70 mg/kg in rat), and inhibits the release of inflammatory mediators from human leukocytes and mast cells (effective dose ~ 100 μM)
Uses expectorant Ambroxol is a metabolite of Bromohexine. Ambroxol Hydrochloride is a bronchosecretolytic drug. Free base of Ambroxol Hydrochloride (A575900).
Therapeutic Function Expectorant

Technology Process of Ambroxol

There total 15 articles about Ambroxol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.9%