3-chloro-N-[3-[3-(dimethylamino)phenyl]-6-methyl-2-(1H-pyrazol-4-yl)thieno[2,3-b]pyridin-4-yl]benzenesulfonamide

Base Information

Chemical Name:3-chloro-N-[3-[3-(dimethylamino)phenyl]-6-methyl-2-(1H-pyrazol-4-yl)thieno[2,3-b]pyridin-4-yl]benzenesulfonamide
CAS No.:1312593-82-0
Molecular Formula:C₂₅H₂₂ClN₅O₂S₂
Molecular Weight:524.067
Hs Code.:

Synonyms:3-chloro-N-[3-[3-(dimethylamino)phenyl]-6-methyl-2-(1H-pyrazol-4-yl)thieno[2,3-b]pyridin-4-yl]benzenesulfonamide

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Chemical Property of 3-chloro-N-[3-[3-(dimethylamino)phenyl]-6-methyl-2-(1H-pyrazol-4-yl)thieno[2,3-b]pyridin-4-yl]benzenesulfonamide

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Technology Process of 3-chloro-N-[3-[3-(dimethylamino)phenyl]-6-methyl-2-(1H-pyrazol-4-yl)thieno[2,3-b]pyridin-4-yl]benzenesulfonamide

There total 9 articles about 3-chloro-N-[3-[3-(dimethylamino)phenyl]-6-methyl-2-(1H-pyrazol-4-yl)thieno[2,3-b]pyridin-4-yl]benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 178752-79-9
3-(N,N-dimethylamino)phenylboronic acid

: 1312595-04-2
1,1-dimethylethyl 4-(3-bromo-4-{[(3-chlorophenyl)sulfonyl]amino}-6-methylthieno[2,3-b]pyridin-2-yl)-1H-pyrazole-1-carboxylate

: 1312593-82-0
3-chloro-N-[3-[3-(dimethylamino)phenyl]-6-methyl-2-(1H-pyrazol-4-yl)thieno[2,3-b]pyridin-4-yl]benzenesulfonamide

Guidance literature:: With water; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; N,N-dimethyl-formamide; at 110 ℃; for 0.5h; Product distribution / selectivity; microwave irradiation;

Reference yield:

: 178752-79-9
3-(N,N-dimethylamino)phenylboronic acid

: 1312593-80-8
N-[3-bromo-6-methyl-2-(1H-pyrazol-4-yl)thieno[2,3-b]pyridin-4-yl]-3-chlorobenzenesulfonamide

: 1312593-82-0
3-chloro-N-[3-[3-(dimethylamino)phenyl]-6-methyl-2-(1H-pyrazol-4-yl)thieno[2,3-b]pyridin-4-yl]benzenesulfonamide

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; N,N-dimethyl-formamide; at 110 ℃; for 22h; Product distribution / selectivity;

Reference yield:

: 1312595-00-8
ethyl 2-bromo-4-{[(3-chlorophenyl)sulfonyl]amino}-6-methylthieno[2,3-b]pyridine-5-carboxylate

: 1312593-82-0
3-chloro-N-[3-[3-(dimethylamino)phenyl]-6-methyl-2-(1H-pyrazol-4-yl)thieno[2,3-b]pyridin-4-yl]benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; 1,4-dioxane; water / 2 h / 100 °C

2.1: bromine / chloroform / 4 h / 60 °C

3.1: sodium hydroxide; water / dimethyl sulfoxide / 1.5 h / 150 °C

3.2: 20 °C / pH ~ 4 - 5

3.3: 1 h / 200 °C

4.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; 1,4-dioxane; water / 22 h / 110 °C

With water; bromine; potassium carbonate; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; chloroform; water; dimethyl sulfoxide; N,N-dimethyl-formamide;