N-{[3-(3,4-dimethoxybenzyl)-1-(1-formylpiperidin-4-yl)-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl]methyl}acetamide

Base Information

Chemical Name:N-{[3-(3,4-dimethoxybenzyl)-1-(1-formylpiperidin-4-yl)-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl]methyl}acetamide
CAS No.:1140589-80-5
Molecular Formula:C₂₆H₃₀N₄O₆
Molecular Weight:494.547
Hs Code.:

Synonyms:N-{[3-(3,4-dimethoxybenzyl)-1-(1-formylpiperidin-4-yl)-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl]methyl}acetamide

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Chemical Property of N-{[3-(3,4-dimethoxybenzyl)-1-(1-formylpiperidin-4-yl)-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl]methyl}acetamide

Chemical Property:

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Technology Process of N-{[3-(3,4-dimethoxybenzyl)-1-(1-formylpiperidin-4-yl)-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl]methyl}acetamide

There total 11 articles about N-{[3-(3,4-dimethoxybenzyl)-1-(1-formylpiperidin-4-yl)-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl]methyl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1140590-98-2
N-{[3-(3,4-dimethoxybenzyl)-2,4-dioxo-1-(piperidin-4-yl)-1,2,3,4-tetrahydroquinazolin-6-yl]methyl}acetamide

: 16712-16-6,64165-14-6,65387-22-6,70179-79-2,540-69-2
ammonium formate

: 1140589-80-5
N-{[3-(3,4-dimethoxybenzyl)-1-(1-formylpiperidin-4-yl)-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl]methyl}acetamide

Guidance literature:: In acetonitrile; at 140 ℃; for 1h; Microwave irradiation;

Reference yield:

: 1140590-98-2
N-{[3-(3,4-dimethoxybenzyl)-2,4-dioxo-1-(piperidin-4-yl)-1,2,3,4-tetrahydroquinazolin-6-yl]methyl}acetamide

: 1140589-80-5
N-{[3-(3,4-dimethoxybenzyl)-1-(1-formylpiperidin-4-yl)-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl]methyl}acetamide

Guidance literature:: With ammonium formate; In quinoclamine;

Reference yield:

: 1140590-94-8
benzyl 4-{[4-({[(1,1-dimethylethoxy) carbonyl]amino}-methyl)-2-(methoxycarbonyl)phenyl](ethoxycarbonyl)amino}piperidine-1-carboxylate

: 1140589-80-5
N-{[3-(3,4-dimethoxybenzyl)-1-(1-formylpiperidin-4-yl)-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl]methyl}acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: water; lithium hydroxide / tetrahydrofuran / 16 h / 20 - 100 °C / Microwave irradiation

1.2: 0.5 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3.1: triethylamine / dichloromethane / 1 h / 20 °C

4.1: ammonium formate / palladium 10% on activated carbon / ethanol / 0.5 h / 800 °C / Inert atmosphere; Microwave irradiation

5.1: acetonitrile / 1 h / 140 °C / Microwave irradiation

With water; ammonium formate; triethylamine; trifluoroacetic acid; lithium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;