2-(2-Chlorophenyl)-4-ethoxyquinazoline

Base Information

• Chemical Name: 2-(2-Chlorophenyl)-4-ethoxyquinazoline
• CAS No.: 59524-97-9
• Molecular Formula: C₁₆H₁₃ClN₂O
• Molecular Weight: 284.745
• DSSTox Substance ID: DTXSID101324525
• ChEMBL ID: CHEMBL1484865
• Mol file: 59524-97-9.mol

Synonyms:2-(2-chlorophenyl)-4-ethoxyquinazoline;MLS001029954;CHEMBL1484865;DTXSID101324525;HMS2806N11;STL325142;AKOS022108240;59524-97-9;SMR000426960;2-(2-Chloro-phenyl)-4-ethoxy-quinazoline

Chemical Property of 2-(2-Chlorophenyl)-4-ethoxyquinazoline

Chemical Property:

• XLogP3: 4.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 284.0716407
• Heavy Atom Count: 20
• Complexity: 315

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCOC1=NC(=NC2=CC=CC=C21)C3=CC=CC=C3Cl

Technology Process of 2-(2-Chlorophenyl)-4-ethoxyquinazoline

There total 2 articles about 2-(2-Chlorophenyl)-4-ethoxyquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

2-chloro-N-methoxybenzamide (112664-07-0) + benzimidic acid ethyl ester (825-60-5) → 2-(2-chloro-phenyl)-4-ethoxy-quinazoline (59524-97-9)

Guidance literature:

With silver hexafluoroantimonate; bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; In 1,2-dichloro-ethane; at 120 ℃; for 4h; Sealed tube;

DOI:10.1002/ejoc.202100726

Reference yield:

→ 2-(2-chloro-phenyl)-4-ethoxy-quinazoline (59524-97-9)

Guidance literature:

2--aminobenzamid, Triaethyloxoniumfluoroborat;

upstream raw materials:

2-chloro-N-methoxybenzamide

benzimidic acid ethyl ester