8-<2-deoxy-3,5-di-O-(p-toluoyl)-α-D-erythro-pentofuranosyl>-2-<(2-methylpropionyl)amino>-8H-imidazo<1,2-a>-s-triazin-4-one

Base Information

• Chemical Name: 8-<2-deoxy-3,5-di-O-(p-toluoyl)-α-D-erythro-pentofuranosyl>-2-<(2-methylpropionyl)amino>-8H-imidazo<1,2-a>-s-triazin-4-one
• CAS No.: 110457-89-1
• Molecular Formula: C₃₀H₃₁N₅O₇
• Molecular Weight: 573.605
• Mol file: 110457-89-1.mol

Synonyms:8-<2-deoxy-3,5-di-O-(p-toluoyl)-α-D-erythro-pentofuranosyl>-2-<(2-methylpropionyl)amino>-8H-imidazo<1,2-a>-s-triazin-4-one

Chemical Property of 8-<2-deoxy-3,5-di-O-(p-toluoyl)-α-D-erythro-pentofuranosyl>-2-<(2-methylpropionyl)amino>-8H-imidazo<1,2-a>-s-triazin-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-<2-deoxy-3,5-di-O-(p-toluoyl)-α-D-erythro-pentofuranosyl>-2-<(2-methylpropionyl)amino>-8H-imidazo<1,2-a>-s-triazin-4-one

There total 4 articles about 8-<2-deoxy-3,5-di-O-(p-toluoyl)-α-D-erythro-pentofuranosyl>-2-<(2-methylpropionyl)amino>-8H-imidazo<1,2-a>-s-triazin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride (4330-21-6) + 2-<(2-methylpropionyl)amino>-8H-imidazo<1,2-a>-s-triazin-4-one (110472-07-6) → 8-<2-deoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl>-2-<(2-methylpropionyl)amino>-8H-imidazo<1,2-a>-s-triazin-4-one (110457-90-4) + 8-<2-deoxy-3,5-di-O-(p-toluoyl)-α-D-erythro-pentofuranosyl>-2-<(2-methylpropionyl)amino>-8H-imidazo<1,2-a>-s-triazin-4-one (110457-89-1)

Guidance literature:

With Tris(3,6-dioxaheptyl)amine; potassium carbonate; In acetonitrile; for 1h; Ambient temperature;

DOI:10.1021/jo00232a015

Reference yield: 21.0%

C30H31N5O7 → 8-<2-deoxy-3,5-di-O-(p-toluoyl)-α-D-erythro-pentofuranosyl>-2-<(2-methylpropionyl)amino>-8H-imidazo<1,2-a>-s-triazin-4-one (110457-89-1)

Guidance literature:

In methanol; dichloromethane;

DOI:10.1002/chem.201901276

Reference yield:

2-aminoimidazo<1,2-a>-s-triazin-4(8H)-one (67410-64-4) → 8-<2-deoxy-3,5-di-O-(p-toluoyl)-α-D-erythro-pentofuranosyl>-2-<(2-methylpropionyl)amino>-8H-imidazo<1,2-a>-s-triazin-4-one (110457-89-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / 85percent phosphoric acid / 1 h / Heating

2: 59 percent / K₂CO₃, tris<2-(2-methoxyethoxy)ethyl>amine / acetonitrile / 1 h / Ambient temperature

With phosphoric acid; Tris(3,6-dioxaheptyl)amine; potassium carbonate; In acetonitrile;

DOI:10.1021/jo00232a015

upstream raw materials:

2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride

2-<(2-methylpropionyl)amino>-8H-imidazo<1,2-a>-s-triazin-4-one

2-aminoimidazo<1,2-a>-s-triazin-4(8H)-one

2-deoxy-3,5-di-O-(p-toluoyl)-α-D-erythro-pentofuranosyl chloride