(R)-2-methyl-N-((R)-(2-methyl-3-oxo-2-azabicyclo[2.2.2]octan-1-yl)(phenyl)methyl)propane-2-sulfinamide

Base Information

Chemical Name:(R)-2-methyl-N-((R)-(2-methyl-3-oxo-2-azabicyclo[2.2.2]octan-1-yl)(phenyl)methyl)propane-2-sulfinamide
CAS No.:1108615-86-6
Molecular Formula:C₁₉H₂₈N₂O₂S
Molecular Weight:348.51
Hs Code.:

Synonyms:(R)-2-methyl-N-((R)-(2-methyl-3-oxo-2-azabicyclo[2.2.2]octan-1-yl)(phenyl)methyl)propane-2-sulfinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-methyl-N-((R)-(2-methyl-3-oxo-2-azabicyclo[2.2.2]octan-1-yl)(phenyl)methyl)propane-2-sulfinamide

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Technology Process of (R)-2-methyl-N-((R)-(2-methyl-3-oxo-2-azabicyclo[2.2.2]octan-1-yl)(phenyl)methyl)propane-2-sulfinamide

There total 5 articles about (R)-2-methyl-N-((R)-(2-methyl-3-oxo-2-azabicyclo[2.2.2]octan-1-yl)(phenyl)methyl)propane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1108615-85-5
(R,E)-2-methyl-N-((2-methyl-3-oxo-2-azabicyclo[2.2.2]octan-1-yl)methylene)propane-2-sulfinamide

: 591-51-5
phenyllithium

: 1108615-86-6
(R)-2-methyl-N-((R)-(2-methyl-3-oxo-2-azabicyclo[2.2.2]octan-1-yl)(phenyl)methyl)propane-2-sulfinamide

Guidance literature:: (R,E)-2-methyl-N-((2-methyl-3-oxo-2-azabicyclo[2.2.2]octan-1-yl)methylene)propane-2-sulfinamide; phenyllithium; With trimethylaluminum; In tetrahydrofuran; dibutyl ether; toluene; at -78 ℃; for 0.833333h;

With ammonia; water; ammonium chloride; In tetrahydrofuran; dibutyl ether; toluene;

Reference yield:

: 1239322-68-9
(R)-2-methyl-N-((2-methyl-3-oxo-2-azabicyclo[2.2.2]octan-1-yl)methylene)propane-2-sulfinamide

: 591-51-5
phenyllithium

: 1108615-86-6
(R)-2-methyl-N-((R)-(2-methyl-3-oxo-2-azabicyclo[2.2.2]octan-1-yl)(phenyl)methyl)propane-2-sulfinamide

Guidance literature:: (R)-2-methyl-N-((2-methyl-3-oxo-2-azabicyclo[2.2.2]octan-1-yl)methylene)propane-2-sulfinamide; phenyllithium; With trimethylaluminum; In tetrahydrofuran; dibutyl ether; toluene; at -78 ℃;

With ammonium hydroxide; ammonium chloride; In tetrahydrofuran; dibutyl ether; water; toluene;

Reference yield:

: 21239-95-2
3-oxo-2-aza-bicyclo[2.2.2]octane-1-carboxylic acid methyl ester

: 1108615-86-6
(R)-2-methyl-N-((R)-(2-methyl-3-oxo-2-azabicyclo[2.2.2]octan-1-yl)(phenyl)methyl)propane-2-sulfinamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / N,N-dimethyl-formamide

2: lithium aluminium tetrahydride / tetrahydrofuran / -78 °C

3: titanium(IV) tetraethanolate / tetrahydrofuran

4: trimethylaluminum / tetrahydrofuran; diethyl ether / -78 °C

With titanium(IV) tetraethanolate; lithium aluminium tetrahydride; trimethylaluminum; sodium hydride; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2018.02.029