4-(3-methoxyphenylamino)pyrrolo[2,1-f][1,2,4]triazin-5-ylmethyl triethylammonium bromide

Base Information

• Chemical Name: 4-(3-methoxyphenylamino)pyrrolo[2,1-f][1,2,4]triazin-5-ylmethyl triethylammonium bromide
• CAS No.: 859855-15-5
• Molecular Formula: Br*C₂₀H₂₈N₅O
• Molecular Weight: 434.379

Synonyms:4-(3-methoxyphenylamino)pyrrolo[2,1-f][1,2,4]triazin-5-ylmethyl triethylammonium bromide

Chemical Property of 4-(3-methoxyphenylamino)pyrrolo[2,1-f][1,2,4]triazin-5-ylmethyl triethylammonium bromide

Chemical Property:

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Technology Process of 4-(3-methoxyphenylamino)pyrrolo[2,1-f][1,2,4]triazin-5-ylmethyl triethylammonium bromide

There total 1 articles about 4-(3-methoxyphenylamino)pyrrolo[2,1-f][1,2,4]triazin-5-ylmethyl triethylammonium bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloro-5-methylpyrrolo[2,1-f][1,2,4]triazine (529508-56-3) + m-Anisidine (536-90-3,918666-97-4) + triethylamine (121-44-8) → 4-(3-methoxyphenylamino)pyrrolo[2,1-f][1,2,4]triazin-5-ylmethyl triethylammonium bromide (859855-15-5) + C20H27BrN5O(1+)*Br(1-)

Guidance literature:

4-chloro-5-methylpyrrolo[2,1-f][1,2,4]triazine; With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In chlorobenzene; at 80 ℃;

triethylamine; In dichloromethane;

m-Anisidine; In toluene; at 55 ℃; Overall yield = 94 %;

DOI:10.1021/op300252n

Reference yield: 99.0%

(3S,4S)-methyl 4-(benzyloxycarbonylamino)piperidine-3-carboxylate (859855-40-6) + 4-(3-methoxyphenylamino)pyrrolo[2,1-f][1,2,4]triazin-5-ylmethyl triethylammonium bromide (859855-15-5) → (3S,4S)-methyl 4-(benzyloxycarbonylamino)-1-((4-(3-methoxyphenylamino)pyrrolo[2,1-f][1,2,4]triazin-5-yl)methyl)piperidine-3-carboxylate

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 55 ℃; for 12h;

Reference yield: 89.0%

C15H20N2O4 + 4-(3-methoxyphenylamino)pyrrolo[2,1-f][1,2,4]triazin-5-ylmethyl triethylammonium bromide (859855-15-5) → (3R,4R)-methyl 4-(benzyloxycarbonylamino)-1-((4-(3-methoxyphenylamino)pyrrolo[2,1-f][1,2,4]triazin-5-yl)methyl)piperidine-3-carboxylate

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 55 ℃; for 12h;

upstream raw materials:

4-chloro-5-methylpyrrolo[2,1-f][1,2,4]triazine

m-Anisidine

triethylamine

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