5-[2-(4-diphenylamino-phenyl)-vinyl]-thiophene-2-carbaldehyde

Base Information

• Chemical Name: 5-[2-(4-diphenylamino-phenyl)-vinyl]-thiophene-2-carbaldehyde
• CAS No.: 945230-80-8
• Molecular Formula: C₂₅H₁₉NOS
• Molecular Weight: 381.498
• Mol file: 945230-80-8.mol

Synonyms:5-[2-(4-diphenylamino-phenyl)-vinyl]-thiophene-2-carbaldehyde

Chemical Property of 5-[2-(4-diphenylamino-phenyl)-vinyl]-thiophene-2-carbaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-[2-(4-diphenylamino-phenyl)-vinyl]-thiophene-2-carbaldehyde

There total 4 articles about 5-[2-(4-diphenylamino-phenyl)-vinyl]-thiophene-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

N,N-dimethyl-formamide (68-12-2,33513-42-7) + (E)-N,N-diphenyl-4-(2-(thiophen-2-yl)vinyl)aniline (1042977-81-0) → 5-[2-(4-diphenylamino-phenyl)-vinyl]-thiophene-2-carbaldehyde (945230-80-8)

Guidance literature:

(E)-N,N-diphenyl-4-(2-(thiophen-2-yl)vinyl)aniline; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 0 ℃; for 16h; Inert atmosphere;

N,N-dimethyl-formamide; In tetrahydrofuran; hexane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.jorganchem.2012.10.012

Reference yield:

4-(diphenylamino)benzaldehyde (4181-05-9) → 5-[2-(4-diphenylamino-phenyl)-vinyl]-thiophene-2-carbaldehyde (945230-80-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: t-BuOK / tetrahydrofuran / 24 h / Heating

2.1: n-butyl lithium / tetrahydrofuran; hexane / -78 - 0 °C

2.2: 1.1 g / tetrahydrofuran; hexane / 2 h / 20 °C

With n-butyllithium; potassium tert-butylate; In tetrahydrofuran; hexane; 1.1: Wittig reaction;

DOI:10.1039/b603002e

Reference yield:

C24H19NS (302965-24-8) → 5-[2-(4-diphenylamino-phenyl)-vinyl]-thiophene-2-carbaldehyde (945230-80-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: iodine / chloroform / 16 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 16 h / -78 - 0 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

With n-butyllithium; iodine; In tetrahydrofuran; hexane; chloroform;

DOI:10.1016/j.jorganchem.2012.10.012

upstream raw materials:

N,N-dimethyl-formamide

(E)-N,N-diphenyl-4-(2-(thiophen-2-yl)vinyl)aniline

4-(diphenylamino)benzaldehyde

C₂₄H₁₉NS

Downstream raw materials:

C₃₆H₂₉NO₂S₂Si

C₃₄H₃₃NO₂S₂Si