3-(2,2-dimethylchroman-6-carboxamido)-7-methoxy-6-(4-methoxyphenyl)-8-methyl-2-oxo-2H-chromen-4-yl 4-methylbenzenesulfonate

Base Information

Chemical Name:3-(2,2-dimethylchroman-6-carboxamido)-7-methoxy-6-(4-methoxyphenyl)-8-methyl-2-oxo-2H-chromen-4-yl 4-methylbenzenesulfonate
CAS No.:1620841-80-6
Molecular Formula:C₃₇H₃₅NO₉S
Molecular Weight:669.752
Hs Code.:

Synonyms:3-(2,2-dimethylchroman-6-carboxamido)-7-methoxy-6-(4-methoxyphenyl)-8-methyl-2-oxo-2H-chromen-4-yl 4-methylbenzenesulfonate

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Chemical Property of 3-(2,2-dimethylchroman-6-carboxamido)-7-methoxy-6-(4-methoxyphenyl)-8-methyl-2-oxo-2H-chromen-4-yl 4-methylbenzenesulfonate

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Technology Process of 3-(2,2-dimethylchroman-6-carboxamido)-7-methoxy-6-(4-methoxyphenyl)-8-methyl-2-oxo-2H-chromen-4-yl 4-methylbenzenesulfonate

There total 6 articles about 3-(2,2-dimethylchroman-6-carboxamido)-7-methoxy-6-(4-methoxyphenyl)-8-methyl-2-oxo-2H-chromen-4-yl 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1620841-68-0
N-(4-hydroxy-7-methoxy-6-(4-methoxyphenyl)-8-methyl-2-oxo-2H-chromen-3-yl)-2,2-dimethylchroman-6-carboxamide

: 98-59-9
p-toluenesulfonyl chloride

: 1620841-80-6
3-(2,2-dimethylchroman-6-carboxamido)-7-methoxy-6-(4-methoxyphenyl)-8-methyl-2-oxo-2H-chromen-4-yl 4-methylbenzenesulfonate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 12.0833h; Inert atmosphere;
DOI:10.1016/j.ejmech.2014.06.067

Reference yield:

: 1620841-73-7
N-(6-bromo-4,7-dimethoxy-8-methyl-2-oxo-2H-chromen-3-yl)-2,2-dimethylchroman-6-carboxamide

: 1620841-80-6
3-(2,2-dimethylchroman-6-carboxamido)-7-methoxy-6-(4-methoxyphenyl)-8-methyl-2-oxo-2H-chromen-4-yl 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium fluoride; palladium diacetate; XPhos / tetrahydrofuran / 24 h / Inert atmosphere; Reflux

2: triethylamine / N,N-dimethyl-formamide / 0.5 h / 120 °C / Schlenk technique

3: triethylamine / dichloromethane / 12.08 h / 20 °C / Inert atmosphere

With potassium fluoride; palladium diacetate; triethylamine; XPhos; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2014.06.067

Reference yield:

: 1654766-44-5
C₂₂H₂₀BrNO₆

: 1620841-80-6
3-(2,2-dimethylchroman-6-carboxamido)-7-methoxy-6-(4-methoxyphenyl)-8-methyl-2-oxo-2H-chromen-4-yl 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

2: potassium fluoride; palladium diacetate; XPhos / tetrahydrofuran / 24 h / Inert atmosphere; Reflux

3: triethylamine / N,N-dimethyl-formamide / 0.5 h / 120 °C / Schlenk technique

4: triethylamine / dichloromethane / 12.08 h / 20 °C / Inert atmosphere

With potassium fluoride; palladium diacetate; potassium carbonate; triethylamine; XPhos; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 2: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2014.06.067