2-(t-butyloxycarbonylamino)-4-(dimethylphosphono)butanoylleucine benzyl ester

Base Information

Chemical Name:2-(t-butyloxycarbonylamino)-4-(dimethylphosphono)butanoylleucine benzyl ester
CAS No.:130568-14-8
Molecular Formula:C₂₄H₃₉N₂O₈P
Molecular Weight:514.556
Hs Code.:

Synonyms:2-(t-butyloxycarbonylamino)-4-(dimethylphosphono)butanoylleucine benzyl ester

Suppliers and Price of 2-(t-butyloxycarbonylamino)-4-(dimethylphosphono)butanoylleucine benzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(t-butyloxycarbonylamino)-4-(dimethylphosphono)butanoylleucine benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(t-butyloxycarbonylamino)-4-(dimethylphosphono)butanoylleucine benzyl ester

There total 7 articles about 2-(t-butyloxycarbonylamino)-4-(dimethylphosphono)butanoylleucine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 2462-35-3
L-leucine benzyl ester hydrochloride

: 120286-26-2
(S)-2-(tert-Butyloxycarbonylamino)-4-dimethoxyphosphorylbutanoate

: 130568-14-8
2-(t-butyloxycarbonylamino)-4-(dimethylphosphono)butanoylleucine benzyl ester

Guidance literature:: With 4-methyl-morpholine; isobutyl chloroformate; at -20 ℃;
DOI:10.1016/S0040-4039(00)97464-1

Reference yield:

: 130568-04-6
t-butyl (2S,4RS)-2-(t-butoxycarbonylamino)-4-(dimethylphosphono)-4-hydroxybutanoate

: 130568-14-8
2-(t-butyloxycarbonylamino)-4-(dimethylphosphono)butanoylleucine benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 99 percent / 1,2-dichloro-ethane / 0.25 h / 50 °C

2: 95 percent / Bu₃SnH / benzene / 1.5 h / Heating

3: 96 percent / 1 h / 20 °C

4: 66 percent / Na₂CO₃ / dioxane; H₂O / 2 h / 0 °C

5: N-methylmorpholine / tetrahydrofuran / 0.05 h / -20 °C

6: N-methylmorpholine / tetrahydrofuran / 2.5 h / -20 °C

With 4-methyl-morpholine; tri-n-butyl-tin hydride; sodium carbonate; In tetrahydrofuran; 1,4-dioxane; water; 1,2-dichloro-ethane; benzene;

Reference yield:

: 130568-05-7
t-butyl (2S,4RS)-2-(t-butoxycarbonylamino)-4-(dimethylphosphono)-4-(imidazolylthiocarbonyloxy)butanoate

: 130568-14-8
2-(t-butyloxycarbonylamino)-4-(dimethylphosphono)butanoylleucine benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / Bu₃SnH / benzene / 1.5 h / Heating

2: 96 percent / 1 h / 20 °C

3: 66 percent / Na₂CO₃ / dioxane; H₂O / 2 h / 0 °C

4: N-methylmorpholine / tetrahydrofuran / 0.05 h / -20 °C

5: N-methylmorpholine / tetrahydrofuran / 2.5 h / -20 °C

With 4-methyl-morpholine; tri-n-butyl-tin hydride; sodium carbonate; In tetrahydrofuran; 1,4-dioxane; water; benzene;