ethyl 2-phenoxy-2-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)propanoate

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Chemical Name:ethyl 2-phenoxy-2-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)propanoate
CAS No.:1264294-94-1
Molecular Formula:C₂₄H₂₀F₃N₃O₃
Molecular Weight:455.436
Hs Code.:

Synonyms:ethyl 2-phenoxy-2-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)propanoate

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Chemical Property of ethyl 2-phenoxy-2-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)propanoate

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Technology Process of ethyl 2-phenoxy-2-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)propanoate

There total 4 articles about ethyl 2-phenoxy-2-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1264296-11-8
ethyl 5-(dimethylamino)-2-methyl-3-oxo-2-phenoxypent-4-enoate

: 6804-53-1
4-(4-(trifluoromethyl)phenyl)-1H-pyrazol-5-amine

: 1264294-94-1
ethyl 2-phenoxy-2-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)propanoate

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; ethanol; at 120 ℃; for 0.166667h; Irradiation with microwave;

Reference yield:

: 609-14-3
2-acetylpropanoic acid ethyl ester

: 1264294-94-1
ethyl 2-phenoxy-2-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 1 h / 0 °C

1.2: 1 h / -78 °C

2.1: caesium carbonate / toluene / 2 h / 120 °C

3.1: 16 h / 100 °C

4.1: hydrogenchloride / 1,4-dioxane; ethanol / 0.17 h / 120 °C / Irradiation with microwave

With hydrogenchloride; sodium hydride; caesium carbonate; In tetrahydrofuran; 1,4-dioxane; ethanol; toluene;

Reference yield:

: 32116-05-5
ethyl 2-bromo-2-methyl-3-oxobutanoate

: 1264294-94-1
ethyl 2-phenoxy-2-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / toluene / 2 h / 120 °C

2: 16 h / 100 °C

3: hydrogenchloride / 1,4-dioxane; ethanol / 0.17 h / 120 °C / Irradiation with microwave

With hydrogenchloride; caesium carbonate; In 1,4-dioxane; ethanol; toluene;