6-(benzyloxy)-3-(4-bromophenyl)-7-methoxy-1,4-dihydroindeno[1,2-c]pyrazole

Base Information

• Chemical Name: 6-(benzyloxy)-3-(4-bromophenyl)-7-methoxy-1,4-dihydroindeno[1,2-c]pyrazole
• CAS No.: 760992-28-7
• Molecular Formula: C₂₄H₁₉BrN₂O₂
• Molecular Weight: 447.331
• Mol file: 760992-28-7.mol

Synonyms:6-(benzyloxy)-3-(4-bromophenyl)-7-methoxy-1,4-dihydroindeno[1,2-c]pyrazole

Chemical Property of 6-(benzyloxy)-3-(4-bromophenyl)-7-methoxy-1,4-dihydroindeno[1,2-c]pyrazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(benzyloxy)-3-(4-bromophenyl)-7-methoxy-1,4-dihydroindeno[1,2-c]pyrazole

There total 7 articles about 6-(benzyloxy)-3-(4-bromophenyl)-7-methoxy-1,4-dihydroindeno[1,2-c]pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

5-(benzyloxy)-2-(4-bromobenzoyl)-6-methoxyindan-1-one (760992-27-6) → 6-(benzyloxy)-3-(4-bromophenyl)-7-methoxy-1,4-dihydroindeno[1,2-c]pyrazole (760992-28-7)

Guidance literature:

With acetic acid; hydrazine; In ethanol;

DOI:10.1016/j.bmcl.2007.05.027

Reference yield:

5-hydroxy-6-methoxy-2,3-dihydro-1H-inden-1-one (127399-78-4) → 6-(benzyloxy)-3-(4-bromophenyl)-7-methoxy-1,4-dihydroindeno[1,2-c]pyrazole (760992-28-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 76 percent / K₂CO₃; NaI / acetone

2: 85 percent / NaH / tetrahydrofuran

3: 92 percent / NH₂NH₂; AcOH / ethanol

With sodium hydride; potassium carbonate; acetic acid; sodium iodide; hydrazine; In tetrahydrofuran; ethanol; acetone;

DOI:10.1016/j.bmcl.2007.05.027

Reference yield:

5,6-dimethoxy-1-indanone (2107-69-9) → 6-(benzyloxy)-3-(4-bromophenyl)-7-methoxy-1,4-dihydroindeno[1,2-c]pyrazole (760992-28-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 49 percent / NaCN / dimethylsulfoxide / 100 °C

2: 76 percent / K₂CO₃; NaI / acetone

3: 85 percent / NaH / tetrahydrofuran

4: 92 percent / NH₂NH₂; AcOH / ethanol

With sodium cyanide; sodium hydride; potassium carbonate; acetic acid; sodium iodide; hydrazine; In tetrahydrofuran; ethanol; dimethyl sulfoxide; acetone;

DOI:10.1016/j.bmcl.2007.05.027

upstream raw materials:

5-(benzyloxy)-2-(4-bromobenzoyl)-6-methoxyindan-1-one

5-hydroxy-6-methoxy-2,3-dihydro-1H-inden-1-one

5,6-dimethoxy-1-indanone

4-Bromobenzoic acid