2-(ethylamino)-6-(3-(4-(trifluoromethoxy)phenyl)propanoyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4-carboxamide

Base Information

Chemical Name:2-(ethylamino)-6-(3-(4-(trifluoromethoxy)phenyl)propanoyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4-carboxamide
CAS No.:1412452-70-0
Molecular Formula:C₂₀H₂₂F₃N₅O₃
Molecular Weight:437.422
Hs Code.:

Synonyms:2-(ethylamino)-6-(3-(4-(trifluoromethoxy)phenyl)propanoyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4-carboxamide

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Chemical Property of 2-(ethylamino)-6-(3-(4-(trifluoromethoxy)phenyl)propanoyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4-carboxamide

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Technology Process of 2-(ethylamino)-6-(3-(4-(trifluoromethoxy)phenyl)propanoyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4-carboxamide

There total 9 articles about 2-(ethylamino)-6-(3-(4-(trifluoromethoxy)phenyl)propanoyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1412452-63-1
C₁₀H₁₅N₅O*ClH

: 886499-74-7
3-[4-(trifluoromethoxy)phenyl]propanoic acid

: 1412452-70-0
2-(ethylamino)-6-(3-(4-(trifluoromethoxy)phenyl)propanoyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4-carboxamide

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 18h; Inert atmosphere;
DOI:10.1021/ml300277t

Reference yield:

: C₂₀H₂₀F₃N₅O₃

: 1412452-70-0
2-(ethylamino)-6-(3-(4-(trifluoromethoxy)phenyl)propanoyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4-carboxamide

Guidance literature:: With triethylsilane; palladium 10% on activated carbon; In methanol; at 20 ℃; Inert atmosphere;
DOI:10.1021/ml300277t

Reference yield:

: 1412452-62-0
C₁₈H₂₈N₂O₆

: 1412452-70-0
2-(ethylamino)-6-(3-(4-(trifluoromethoxy)phenyl)propanoyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / ethanol / 18 h / Inert atmosphere; Reflux

2: ammonia / methanol / 18 h / 40 °C / Inert atmosphere; Sealed tube

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

4: tetrahydrofuran / 18 h / 80 °C / Inert atmosphere

5: hydrogenchloride / dichloromethane; 1,4-dioxane / 6 h / 0 - 20 °C / Inert atmosphere

6: triethylamine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 20 °C / Inert atmosphere

With hydrogenchloride; dmap; ammonia; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane;
DOI:10.1021/ml300277t