(S)-3-[4-(2-Amino-ethoxy)-3-nitro-benzoylamino]-2-benzenesulfonylamino-propionic acid benzyl ester

Base Information

Chemical Name:(S)-3-[4-(2-Amino-ethoxy)-3-nitro-benzoylamino]-2-benzenesulfonylamino-propionic acid benzyl ester
CAS No.:215050-07-0
Molecular Formula:C₂₅H₂₆N₄O₈S
Molecular Weight:542.569
Hs Code.:

Synonyms:(S)-3-[4-(2-Amino-ethoxy)-3-nitro-benzoylamino]-2-benzenesulfonylamino-propionic acid benzyl ester

Suppliers and Price of (S)-3-[4-(2-Amino-ethoxy)-3-nitro-benzoylamino]-2-benzenesulfonylamino-propionic acid benzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-3-[4-(2-Amino-ethoxy)-3-nitro-benzoylamino]-2-benzenesulfonylamino-propionic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-3-[4-(2-Amino-ethoxy)-3-nitro-benzoylamino]-2-benzenesulfonylamino-propionic acid benzyl ester

There total 10 articles about (S)-3-[4-(2-Amino-ethoxy)-3-nitro-benzoylamino]-2-benzenesulfonylamino-propionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 453-71-4
3-nitro-4-fluorobenzoic acid

: 215050-07-0
(S)-3-[4-(2-Amino-ethoxy)-3-nitro-benzoylamino]-2-benzenesulfonylamino-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 98 percent / toluene / 8 h / 80 °C

2: 73 percent / molecular sieves 4A / Bu₄NF / dimethylformamide / 4 h / 25 °C

3: 99 percent / LiOH*H₂O / H₂O; dioxane / 4 h / 25 °C

4: 82 percent / DCC / 4-DMAP / CH₂Cl₂ / 4 h / 25 °C

5: 84 percent / CF₃CO₂H / CH₂Cl₂ / 2 h / 25 °C / Acid hydrolysis

6: 78 percent / i-Pr₂NEt / CH₂Cl₂ / 4 h / 25 °C

7: Ph₃P; H₂O / tetrahydrofuran / 12 h / 25 °C

With lithium hydroxide; 4 A molecular sieve; water; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; triphenylphosphine; trifluoroacetic acid; dmap; tetrabutyl ammonium fluoride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; toluene; 1: Esterification / 2: Substitution / 3: Hydrolysis / 4: Substitution / 5: Hydrolysis / 6: Substitution / 7: Reduction;
DOI:10.1016/S0968-0896(98)00090-X

Reference yield:

: 13512-57-7
N-[(1,1-dimethylethoxycarbonyl)amino]-L-asparagine benzyl ester

: 215050-07-0
(S)-3-[4-(2-Amino-ethoxy)-3-nitro-benzoylamino]-2-benzenesulfonylamino-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 41 percent / PhI(OCOCF₃)2; pyridine / dimethylformamide; H₂O / 3.5 h / 25 °C

2: 82 percent / DCC / 4-DMAP / CH₂Cl₂ / 4 h / 25 °C

3: 84 percent / CF₃CO₂H / CH₂Cl₂ / 2 h / 25 °C / Acid hydrolysis

4: 78 percent / i-Pr₂NEt / CH₂Cl₂ / 4 h / 25 °C

5: Ph₃P; H₂O / tetrahydrofuran / 12 h / 25 °C

With pyridine; water; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; triphenylphosphine; trifluoroacetic acid; bis-[(trifluoroacetoxy)iodo]benzene; dmap; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; 1: Reduction / 2: Substitution / 3: Hydrolysis / 4: Substitution / 5: Reduction;
DOI:10.1016/S0968-0896(98)00090-X

Reference yield:

: 329-59-9
4-fluoro-3-nitro-benzoic acid methyl ester

: 215050-07-0
(S)-3-[4-(2-Amino-ethoxy)-3-nitro-benzoylamino]-2-benzenesulfonylamino-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 73 percent / molecular sieves 4A / Bu₄NF / dimethylformamide / 4 h / 25 °C

2: 99 percent / LiOH*H₂O / H₂O; dioxane / 4 h / 25 °C

3: 82 percent / DCC / 4-DMAP / CH₂Cl₂ / 4 h / 25 °C

4: 84 percent / CF₃CO₂H / CH₂Cl₂ / 2 h / 25 °C / Acid hydrolysis

5: 78 percent / i-Pr₂NEt / CH₂Cl₂ / 4 h / 25 °C

6: Ph₃P; H₂O / tetrahydrofuran / 12 h / 25 °C

With lithium hydroxide; 4 A molecular sieve; water; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; triphenylphosphine; trifluoroacetic acid; dmap; tetrabutyl ammonium fluoride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; 1: Substitution / 2: Hydrolysis / 3: Substitution / 4: Hydrolysis / 5: Substitution / 6: Reduction;
DOI:10.1016/S0968-0896(98)00090-X