Toluene-4-sulfonic acid (1S,3S)-3-(2-chloro-phenyl)-3-methoxycarbonylamino-2-oxo-cyclohexyl ester

Base Information

Chemical Name:Toluene-4-sulfonic acid (1S,3S)-3-(2-chloro-phenyl)-3-methoxycarbonylamino-2-oxo-cyclohexyl ester
CAS No.:103904-72-9
Molecular Formula:C₂₁H₂₂ClNO₆S
Molecular Weight:451.928
Hs Code.:

Synonyms:Toluene-4-sulfonic acid (1S,3S)-3-(2-chloro-phenyl)-3-methoxycarbonylamino-2-oxo-cyclohexyl ester

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Chemical Property of Toluene-4-sulfonic acid (1S,3S)-3-(2-chloro-phenyl)-3-methoxycarbonylamino-2-oxo-cyclohexyl ester

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Technology Process of Toluene-4-sulfonic acid (1S,3S)-3-(2-chloro-phenyl)-3-methoxycarbonylamino-2-oxo-cyclohexyl ester

There total 4 articles about Toluene-4-sulfonic acid (1S,3S)-3-(2-chloro-phenyl)-3-methoxycarbonylamino-2-oxo-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 98-59-9
p-toluenesulfonyl chloride

: 103904-70-7
2-(o-chlorophenyl)-2-<(methoxycarbonyl)amino>-6-hydroxycyclohexanone

: 103904-72-9
Toluene-4-sulfonic acid (1S,3S)-3-(2-chloro-phenyl)-3-methoxycarbonylamino-2-oxo-cyclohexyl ester

Guidance literature:: With pyridine; dmap; In toluene; Ambient temperature;
DOI:10.1021/jm00161a043

Reference yield:

: 35211-10-0,83777-65-5
norketamine

: 103904-72-9
Toluene-4-sulfonic acid (1S,3S)-3-(2-chloro-phenyl)-3-methoxycarbonylamino-2-oxo-cyclohexyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / Na₂CO₃ / benzene / 3 h / Heating

2: 1.) lithium diisopropylamide / 1.) THF, hexane, -78 deg C, 2 h, 2.) THF, hexane, a) from -78 deg C to RT, 20 min, b) RT, 45 min

3: 78 percent / m-chloroperbenzoic acid, Na₂CO₃ / hexane / 3 h / Ambient temperature

4: 42 percent / (dimethylamino)pyridine, pyridine / toluene / Ambient temperature

With pyridine; dmap; sodium carbonate; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; In hexane; toluene; benzene;
DOI:10.1021/jm00161a043

Reference yield:

: 103904-69-4
2-(o-chlorophenyl)-2-<(methoxycarbonyl)amino>cyclohexanone

: 103904-72-9
Toluene-4-sulfonic acid (1S,3S)-3-(2-chloro-phenyl)-3-methoxycarbonylamino-2-oxo-cyclohexyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) lithium diisopropylamide / 1.) THF, hexane, -78 deg C, 2 h, 2.) THF, hexane, a) from -78 deg C to RT, 20 min, b) RT, 45 min

2: 78 percent / m-chloroperbenzoic acid, Na₂CO₃ / hexane / 3 h / Ambient temperature

3: 42 percent / (dimethylamino)pyridine, pyridine / toluene / Ambient temperature

With pyridine; dmap; sodium carbonate; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; In hexane; toluene;
DOI:10.1021/jm00161a043