[3-({2'-[2-((2S,3R)-2-{3-[(2S,3R)-2-tert-Butoxycarbonylamino-3-hydroxy-3-(1-trityl-1H-imidazol-4-yl)-propionylamino]-propionylamino}-3-hydroxy-butyrylamino)-ethyl]-[2,4']bithiazolyl-4-carbonyl}-amino)-propyl]-dimethyl-sulfonium

Base Information

• Chemical Name: [3-({2'-[2-((2S,3R)-2-{3-[(2S,3R)-2-tert-Butoxycarbonylamino-3-hydroxy-3-(1-trityl-1H-imidazol-4-yl)-propionylamino]-propionylamino}-3-hydroxy-butyrylamino)-ethyl]-[2,4']bithiazolyl-4-carbonyl}-amino)-propyl]-dimethyl-sulfonium
• CAS No.: 214402-51-4
• Molecular Formula: C₅₁H₆₂N₉O₈S₃
• Molecular Weight: 1025.31
• Mol file: 214402-51-4.mol

Synonyms:[3-({2'-[2-((2S,3R)-2-{3-[(2S,3R)-2-tert-Butoxycarbonylamino-3-hydroxy-3-(1-trityl-1H-imidazol-4-yl)-propionylamino]-propionylamino}-3-hydroxy-butyrylamino)-ethyl]-[2,4']bithiazolyl-4-carbonyl}-amino)-propyl]-dimethyl-sulfonium

Chemical Property of [3-({2'-[2-((2S,3R)-2-{3-[(2S,3R)-2-tert-Butoxycarbonylamino-3-hydroxy-3-(1-trityl-1H-imidazol-4-yl)-propionylamino]-propionylamino}-3-hydroxy-butyrylamino)-ethyl]-[2,4']bithiazolyl-4-carbonyl}-amino)-propyl]-dimethyl-sulfonium

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [3-({2'-[2-((2S,3R)-2-{3-[(2S,3R)-2-tert-Butoxycarbonylamino-3-hydroxy-3-(1-trityl-1H-imidazol-4-yl)-propionylamino]-propionylamino}-3-hydroxy-butyrylamino)-ethyl]-[2,4']bithiazolyl-4-carbonyl}-amino)-propyl]-dimethyl-sulfonium

There total 2 articles about [3-({2'-[2-((2S,3R)-2-{3-[(2S,3R)-2-tert-Butoxycarbonylamino-3-hydroxy-3-(1-trityl-1H-imidazol-4-yl)-propionylamino]-propionylamino}-3-hydroxy-butyrylamino)-ethyl]-[2,4']bithiazolyl-4-carbonyl}-amino)-propyl]-dimethyl-sulfonium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S,3R)-2-tert-Butoxycarbonylamino-3-hydroxy-3-(1-trityl-1H-imidazol-4-yl)-propionic acid (160054-25-1) + {3-[(2'-{2-[(2S,3R)-2-(3-Amino-propionylamino)-3-hydroxy-butyrylamino]-ethyl}-[2,4']bithiazolyl-4-carbonyl)-amino]-propyl}-dimethyl-sulfonium (214402-47-8) → [3-({2'-[2-((2S,3R)-2-{3-[(2S,3R)-2-tert-Butoxycarbonylamino-3-hydroxy-3-(1-trityl-1H-imidazol-4-yl)-propionylamino]-propionylamino}-3-hydroxy-butyrylamino)-ethyl]-[2,4']bithiazolyl-4-carbonyl}-amino)-propyl]-dimethyl-sulfonium (214402-51-4)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 23 ℃; Yield given;

DOI:10.1021/ja9816640

Reference yield:

{3-[(2'-{2-[(2S,3R)-2-(3-tert-Butoxycarbonylamino-propionylamino)-3-hydroxy-butyrylamino]-ethyl}-[2,4']bithiazolyl-4-carbonyl)-amino]-propyl}-dimethyl-sulfonium; iodide → [3-({2'-[2-((2S,3R)-2-{3-[(2S,3R)-2-tert-Butoxycarbonylamino-3-hydroxy-3-(1-trityl-1H-imidazol-4-yl)-propionylamino]-propionylamino}-3-hydroxy-butyrylamino)-ethyl]-[2,4']bithiazolyl-4-carbonyl}-amino)-propyl]-dimethyl-sulfonium (214402-51-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 3 N HCl / ethyl acetate / 23 °C

2: i-Pr₂NEt, benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate / dimethylformamide / 23 °C

With hydrogenchloride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/ja9816640

upstream raw materials:

(2S,3R)-2-tert-Butoxycarbonylamino-3-hydroxy-3-(1-trityl-1H-imidazol-4-yl)-propionic acid

{3-[(2'-{2-[(2S,3R)-2-(3-Amino-propionylamino)-3-hydroxy-butyrylamino]-ethyl}-[2,4']bithiazolyl-4-carbonyl)-amino]-propyl}-dimethyl-sulfonium