p-nitrobenzyl 7--3-methyl-3-cephem-4-carboxylate

Base Information

Chemical Name:p-nitrobenzyl 7--3-methyl-3-cephem-4-carboxylate
CAS No.:95360-83-1
Molecular Formula:C₃₃H₃₄N₄O₉S
Molecular Weight:662.72
Hs Code.:

p-nitrobenzyl 7-<N-(tert-butoxycarbonyl)(6-methoxy-2-naphthyl)glycylamido>-3-methyl-3-cephem-4-carboxylate

Synonyms:p-nitrobenzyl 7--3-methyl-3-cephem-4-carboxylate

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Chemical Property of p-nitrobenzyl 7--3-methyl-3-cephem-4-carboxylate

Chemical Property:

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Technology Process of p-nitrobenzyl 7--3-methyl-3-cephem-4-carboxylate

There total 7 articles about p-nitrobenzyl 7--3-methyl-3-cephem-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 29124-83-2
p-nitrobenzyl ester of 7-aminodeacetoxycephalosporanic acid

: 95360-82-0
N-(tert-butoxycarbonyl)(6-methoxy-2-naphthyl)glycine

: 95360-83-1
p-nitrobenzyl 7--3-methyl-3-cephem-4-carboxylate

Guidance literature:: With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In acetonitrile; at 25 ℃; for 16h;
DOI:10.1021/jm00150a022

Reference yield:

: 93-04-9
2-Methoxynaphthalene

: 95360-83-1
p-nitrobenzyl 7--3-methyl-3-cephem-4-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) n-butyllithium / 1.) THF, pentane, ether, -100 deg C, 2.) THF, pentane, ether, -100 deg C, 60 min

2: sodium acetate, hydroxylamine hydrochloride / ethanol / 3 h / Heating

3: 90 percent HCO₂H, Zn / methanol / 12 h / 0 °C

4: 1 N NaOH / ethanol / 2 h

5: ethanol

6: 1.3 g / EEDQ / acetonitrile / 16 h / 25 °C

With sodium hydroxide; n-butyllithium; formic acid; hydroxylamine hydrochloride; sodium acetate; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; zinc; In methanol; ethanol; acetonitrile;
DOI:10.1021/jm00150a022

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 95360-83-1
p-nitrobenzyl 7--3-methyl-3-cephem-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol

2: 1.3 g / EEDQ / acetonitrile / 16 h / 25 °C

With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In ethanol; acetonitrile;
DOI:10.1021/jm00150a022