(E)-3-(1-tert-butoxycarbonyl-3-oxo-2-phenyltetrahydropyridazin-4-ylidenemethyl)-4,6-dichloro-1H-indole-2-carboxylic acid

Base Information

• Chemical Name: (E)-3-(1-tert-butoxycarbonyl-3-oxo-2-phenyltetrahydropyridazin-4-ylidenemethyl)-4,6-dichloro-1H-indole-2-carboxylic acid
• CAS No.: 166974-48-7
• Molecular Formula: C₂₅H₂₃Cl₂N₃O₅
• Molecular Weight: 516.381
• Mol file: 166974-48-7.mol

Synonyms:(E)-3-(1-tert-butoxycarbonyl-3-oxo-2-phenyltetrahydropyridazin-4-ylidenemethyl)-4,6-dichloro-1H-indole-2-carboxylic acid

Chemical Property of (E)-3-(1-tert-butoxycarbonyl-3-oxo-2-phenyltetrahydropyridazin-4-ylidenemethyl)-4,6-dichloro-1H-indole-2-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-3-(1-tert-butoxycarbonyl-3-oxo-2-phenyltetrahydropyridazin-4-ylidenemethyl)-4,6-dichloro-1H-indole-2-carboxylic acid

There total 3 articles about (E)-3-(1-tert-butoxycarbonyl-3-oxo-2-phenyltetrahydropyridazin-4-ylidenemethyl)-4,6-dichloro-1H-indole-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

1-tert-butoxycarbonyl-3-formyl-4,6-dichloroindole-2-carboxylic acid ethyl ester (166974-61-4) + 3-oxo-2-phenyltetrahydropyridazine-1-carboxylic acid tert-butyl ester (166974-84-1) → (E)-3-(1-tert-butoxycarbonyl-3-oxo-2-phenyltetrahydropyridazin-4-ylidenemethyl)-4,6-dichloro-1H-indole-2-carboxylic acid (166974-48-7)

Guidance literature:

3-oxo-2-phenyltetrahydropyridazine-1-carboxylic acid tert-butyl ester; With lithium hexamethyldisilazane; In tetrahydrofuran; at -20 ℃; for 0.5h;

1-tert-butoxycarbonyl-3-formyl-4,6-dichloroindole-2-carboxylic acid ethyl ester; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1016/S0014-827X(01)01141-7

Reference yield:

ethyl-3-formyl-4,6-dichloro-indole-2-carboxylate (153435-96-2) → (E)-3-(1-tert-butoxycarbonyl-3-oxo-2-phenyltetrahydropyridazin-4-ylidenemethyl)-4,6-dichloro-1H-indole-2-carboxylic acid (166974-48-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 91 percent / DMAP / CH₂Cl₂ / 1 h

2.1: LiHMDS / tetrahydrofuran / 0.5 h / -20 °C

2.2: 35 percent / tetrahydrofuran / 2 h / 20 °C

With dmap; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0014-827X(01)01141-7

Reference yield:

tert-butyl 2-phenylhydrazine-1-carboxylate (42116-43-8) → (E)-3-(1-tert-butoxycarbonyl-3-oxo-2-phenyltetrahydropyridazin-4-ylidenemethyl)-4,6-dichloro-1H-indole-2-carboxylic acid (166974-48-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 70 percent / K₂CO₃ / dimethylformamide

2.1: LiHMDS / tetrahydrofuran / 0.5 h / -20 °C

2.2: 35 percent / tetrahydrofuran / 2 h / 20 °C

With potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/S0014-827X(01)01141-7

upstream raw materials:

1-tert-butoxycarbonyl-3-formyl-4,6-dichloroindole-2-carboxylic acid ethyl ester

3-oxo-2-phenyltetrahydropyridazine-1-carboxylic acid tert-butyl ester

ethyl-3-formyl-4,6-dichloro-indole-2-carboxylate

tert-butyl 2-phenylhydrazine-1-carboxylate