9,10-dimethoxy-7-methyl-5,8-dihydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolinium; methyl sulfate

Base Information

• Chemical Name: 9,10-dimethoxy-7-methyl-5,8-dihydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolinium; methyl sulfate
• CAS No.: 32245-50-4
• Molecular Formula: CH₃O₄S*C₂₁H₂₂NO₄
• Molecular Weight: 463.508
• Mol file: 32245-50-4.mol

Synonyms:9,10-dimethoxy-7-methyl-5,8-dihydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolinium; methyl sulfate

Chemical Property of 9,10-dimethoxy-7-methyl-5,8-dihydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolinium; methyl sulfate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9,10-dimethoxy-7-methyl-5,8-dihydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolinium; methyl sulfate

There total 1 articles about 9,10-dimethoxy-7-methyl-5,8-dihydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolinium; methyl sulfate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7,8-dihydroberberine (483-15-8) + dimethyl sulfate (77-78-1) → 9,10-dimethoxy-7-methyl-5,8-dihydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolinium; methyl sulfate (32245-50-4)

Guidance literature:

In benzene; for 2.5h; Yield given; Heating;

DOI:10.1248/cpb.39.2712

Reference yield:

9,10-dimethoxy-7-methyl-5,8-dihydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolinium; methyl sulfate (32245-50-4) → 6-anilino-1,2-dimethoxy-12-methyl-5,12-dihydro-6H-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridin-13-one (67249-40-5)

Guidance literature:

Multi-step reaction with 3 steps

1: (i) KOH, MeOH, (ii) DDQ, CHCl₃

2: benzene / Irradiation

3: H₂, aq. HCl / Pd-C / methanol

With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; benzene;

DOI:10.1248/cpb.27.2076

Reference yield:

9,10-dimethoxy-7-methyl-5,8-dihydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolinium; methyl sulfate (32245-50-4) → 12-acetanilidooxychelerythrine (72584-78-2)

Guidance literature:

Multi-step reaction with 5 steps

1: (i) KOH, MeOH, (ii) DDQ, CHCl₃

2: benzene / Irradiation

3: H₂, aq. HCl / Pd-C / methanol

4: Ambient temperature

5: DDQ / dioxane / Heating

With hydrogenchloride; hydrogen; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium on activated charcoal; In 1,4-dioxane; methanol; benzene;

DOI:10.1248/cpb.27.2076

upstream raw materials:

7,8-dihydroberberine

dimethyl sulfate

Downstream raw materials:

oxychelerythrine

4b,10bβ,11,12-tetrahydro-4bβ,12β-(N-phenylepoxyimino)oxychelerythrine

5-acetoxy-1,2,5-trimethoxy-12-methyl-6-phenylimino-5,12-dihydro-6H-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridin-13-one

11,11-diacetoxy-11,12-dihydro-12-phenyliminooxychelerythrine