Technology Process of 2,3-dimethoxy-6-(methoxymethoxy)benzaldehyde
There total 2 articles about 2,3-dimethoxy-6-(methoxymethoxy)benzaldehyde which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1,2-dimethoxy-4-(methoxymethoxy)benzene;
With
n-butyllithium; N,N,N,N,-tetramethylethylenediamine;
In
diethyl ether; hexane;
at 0 ℃;
for 5h;
Inert atmosphere;
N,N-dimethyl-formamide;
In
diethyl ether; hexane;
at 0 ℃;
regioselective reaction;
Inert atmosphere;
DOI:10.1007/s11426-011-4454-0
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Inert atmosphere
2.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / diethyl ether; hexane / 5 h / 0 °C / Inert atmosphere
2.2: 0 °C / Inert atmosphere
With
dmap; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; N-ethyl-N,N-diisopropylamine;
In
diethyl ether; hexane; dichloromethane;
DOI:10.1007/s11426-011-4454-0
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: trimethylsilyl bromide / dichloromethane / 0.5 h / 0 °C / Inert atmosphere
1.2: Inert atmosphere
2.1: pyridine; Iodine monochloride / 1,4-dioxane / 80 h / 0 - 20 °C / Inert atmosphere
3.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 8 h / 80 °C / Inert atmosphere
4.1: sodium tetrahydroborate / methanol / 2 h / 0 °C / Inert atmosphere
5.1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 8 h / 20 °C / Inert atmosphere
With
pyridine; dmap; bis-triphenylphosphine-palladium(II) chloride; sodium tetrahydroborate; copper(l) iodide; trimethylsilyl bromide; Iodine monochloride; triethylamine; N-ethyl-N,N-diisopropylamine;
In
1,4-dioxane; methanol; dichloromethane;
DOI:10.1007/s11426-011-4454-0