4-(2,2-dimethyl-4-p-tolyl-2H-benzo[g]chromen-7-yl)-benzoic acid ethyl ester

Base Information

Chemical Name:4-(2,2-dimethyl-4-p-tolyl-2H-benzo[g]chromen-7-yl)-benzoic acid ethyl ester
CAS No.:204449-03-6
Molecular Formula:C₃₁H₂₈O₃
Molecular Weight:448.562
Hs Code.:

4-(2,2-dimethyl-4-<i>p</i>-tolyl-2<i>H</i>-benzo[<i>g</i>]chromen-7-yl)-benzoic acid ethyl ester

Synonyms:4-(2,2-dimethyl-4-p-tolyl-2H-benzo[g]chromen-7-yl)-benzoic acid ethyl ester

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Chemical Property of 4-(2,2-dimethyl-4-p-tolyl-2H-benzo[g]chromen-7-yl)-benzoic acid ethyl ester

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Technology Process of 4-(2,2-dimethyl-4-p-tolyl-2H-benzo[g]chromen-7-yl)-benzoic acid ethyl ester

There total 8 articles about 4-(2,2-dimethyl-4-p-tolyl-2H-benzo[g]chromen-7-yl)-benzoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 224950-76-9
4-[1-(2,2-dimethoxy-ethyl)-2-(2,2-dimethyl-4-p-tolyl-2H-chromen-6-yl)-vinyl]-benzoic acid ethyl ester

: 204449-03-6
4-(2,2-dimethyl-4-p-tolyl-2H-benzo[g]chromen-7-yl)-benzoic acid ethyl ester

Guidance literature:: With tin(IV) chloride; In dichloromethane; at -78 ℃;
DOI:10.1016/S0960-894X(99)00077-3

Reference yield:

: 123266-62-6
7-bromo-3-methoxy-2-naphthoic acid

: 204449-03-6
4-(2,2-dimethyl-4-p-tolyl-2H-benzo[g]chromen-7-yl)-benzoic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 60 percent / diethyl ether; tetrahydrofuran / 3 h / 20 °C

2: 95 percent / BBr₃ / CH₂Cl₂ / 2 h / -78 - 0 °C

3: 40 percent / piperidinium trifluoroacetate / benzene / 48 h / 100 °C

4: 50 percent / tetrahydrofuran / 2 h / -78 - 0 °C

5: 90 percent / p-TSA / methanol / 16 h / 20 °C

6: 1.) t-BuLi, 2.) B(OMe)3, 3.) Pd(PPh)3)4, K₂CO₃

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; Trimethyl borate; tert.-butyl lithium; boron tribromide; piperidinium 2,2,2-trifluoroacetate; potassium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; benzene;
DOI:10.1016/S0960-894X(99)00180-8

Reference yield:

: 123266-51-3
7-bromo-3-methoxynaphthalene-2-carboxylic acid methyl ester

: 204449-03-6
4-(2,2-dimethyl-4-p-tolyl-2H-benzo[g]chromen-7-yl)-benzoic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: aq. KOH / methanol / 3 h / 80 °C

2: 60 percent / diethyl ether; tetrahydrofuran / 3 h / 20 °C

3: 95 percent / BBr₃ / CH₂Cl₂ / 2 h / -78 - 0 °C

4: 40 percent / piperidinium trifluoroacetate / benzene / 48 h / 100 °C

5: 50 percent / tetrahydrofuran / 2 h / -78 - 0 °C

6: 90 percent / p-TSA / methanol / 16 h / 20 °C

7: 1.) t-BuLi, 2.) B(OMe)3, 3.) Pd(PPh)3)4, K₂CO₃

With potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Trimethyl borate; tert.-butyl lithium; boron tribromide; piperidinium 2,2,2-trifluoroacetate; potassium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; benzene;
DOI:10.1016/S0960-894X(99)00180-8