tert-butyl 4-{[4-(2-butynyloxy)phenyl]sulfonyl}-1,4-diazepane-5-carboxylic acid-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-{[4-(2-butynyloxy)phenyl]sulfonyl}-1,4-diazepane-5-carboxylic acid-1-carboxylate
CAS No.:287408-82-6
Molecular Formula:C₂₁H₂₈N₂O₇S
Molecular Weight:452.529
Hs Code.:

Synonyms:tert-butyl 4-{[4-(2-butynyloxy)phenyl]sulfonyl}-1,4-diazepane-5-carboxylic acid-1-carboxylate

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Chemical Property of tert-butyl 4-{[4-(2-butynyloxy)phenyl]sulfonyl}-1,4-diazepane-5-carboxylic acid-1-carboxylate

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Technology Process of tert-butyl 4-{[4-(2-butynyloxy)phenyl]sulfonyl}-1,4-diazepane-5-carboxylic acid-1-carboxylate

There total 6 articles about tert-butyl 4-{[4-(2-butynyloxy)phenyl]sulfonyl}-1,4-diazepane-5-carboxylic acid-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 287408-81-5
4-{[4-(2-butynyloxy)-phenyl]sulfonyl}-1,4-diazepane-5-carboxylic acid

: tert-Butyl 4-{[4-(2-butynyloxy)phenyl]sulfonyll}-1(hydroxyamino)carbonyl]-1,4-diazepane-1-carboxylate

: 287408-82-6
tert-butyl 4-{[4-(2-butynyloxy)phenyl]sulfonyl}-1,4-diazepane-5-carboxylic acid-1-carboxylate

Guidance literature:: With hydrogenchloride; sodium hydroxide; In 1,4-dioxane; water;

Reference yield:

: 138883-21-3
(+/-)-tert-butyl 1,4-dibenzyl-1,4-diazepane-5-carboxylate

: 287408-82-6
tert-butyl 4-{[4-(2-butynyloxy)phenyl]sulfonyl}-1,4-diazepane-5-carboxylic acid-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / Pd/C

2: aq. NaOH / dioxane

3: Et₃N; DMAP

4: TFA / CH₂Cl₂

5: aq. NaOH / dioxane

With dmap; sodium hydroxide; hydrogen; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In 1,4-dioxane; dichloromethane;
DOI:10.1016/j.bmcl.2005.01.053

Reference yield:

: 138883-20-2
(+/-)-tert-butyl 1,4-diazepane-5-carboxylate

: 287408-82-6
tert-butyl 4-{[4-(2-butynyloxy)phenyl]sulfonyl}-1,4-diazepane-5-carboxylic acid-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: aq. NaOH / dioxane

2: Et₃N; DMAP

3: TFA / CH₂Cl₂

4: aq. NaOH / dioxane

With dmap; sodium hydroxide; triethylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane;
DOI:10.1016/j.bmcl.2005.01.053