tert-butyl 3-(4-(2-iodoethoxy)phenyl)-4-methyl-6-oxo-5,6-dihydropyridazine-1(4H)-carboxylate

Base Information

Chemical Name:tert-butyl 3-(4-(2-iodoethoxy)phenyl)-4-methyl-6-oxo-5,6-dihydropyridazine-1(4H)-carboxylate
CAS No.:1010801-16-7
Molecular Formula:C₁₈H₂₃IN₂O₄
Molecular Weight:458.296
Hs Code.:

Synonyms:tert-butyl 3-(4-(2-iodoethoxy)phenyl)-4-methyl-6-oxo-5,6-dihydropyridazine-1(4H)-carboxylate

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Chemical Property of tert-butyl 3-(4-(2-iodoethoxy)phenyl)-4-methyl-6-oxo-5,6-dihydropyridazine-1(4H)-carboxylate

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Technology Process of tert-butyl 3-(4-(2-iodoethoxy)phenyl)-4-methyl-6-oxo-5,6-dihydropyridazine-1(4H)-carboxylate

There total 2 articles about tert-butyl 3-(4-(2-iodoethoxy)phenyl)-4-methyl-6-oxo-5,6-dihydropyridazine-1(4H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1010801-15-6
2-t-Butoxycarbonyl-6-[4-(2-hydroxyethoxy)phenyl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one

: 1010801-16-7
tert-butyl 3-(4-(2-iodoethoxy)phenyl)-4-methyl-6-oxo-5,6-dihydropyridazine-1(4H)-carboxylate

Guidance literature:: With 1H-imidazole; iodine; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1016/j.bmcl.2012.08.121

Reference yield:

: 1010801-14-5
2-t-Butoxycarbonyl-6-[4-[2-(t-butyldiphenylsilyloxy)ethoxy]phenyl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one

: 1010801-16-7
tert-butyl 3-(4-(2-iodoethoxy)phenyl)-4-methyl-6-oxo-5,6-dihydropyridazine-1(4H)-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 0 - 20 °C

2: 1H-imidazole; triphenylphosphine; iodine / tetrahydrofuran / 1 h / 20 °C

With 1H-imidazole; tetrabutyl ammonium fluoride; iodine; triphenylphosphine; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2012.08.121

Reference yield: 48.0%

: 909719-71-7,1010831-22-7,1010831-23-8
6-[7-methoxy-2-(trifluoromethyl)pyrazolo[1,5-a]pyridin-4-yl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone

: 1010801-16-7
tert-butyl 3-(4-(2-iodoethoxy)phenyl)-4-methyl-6-oxo-5,6-dihydropyridazine-1(4H)-carboxylate

: 1010801-63-4
C₃₂H₃₅F₃N₆O₆

Guidance literature:: 6-[7-methoxy-2-(trifluoromethyl)pyrazolo[1,5-a]pyridin-4-yl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.5h; Inert atmosphere;

tert-butyl 3-(4-(2-iodoethoxy)phenyl)-4-methyl-6-oxo-5,6-dihydropyridazine-1(4H)-carboxylate; In N,N-dimethyl-formamide; mineral oil; at 0 - 80 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.bmcl.2012.08.121