AMG 8163

Base Information

• Chemical Name: AMG 8163
• CAS No.: 659731-59-6
• Molecular Formula: C₂₅H₂₂F₃N₅O₄S
• Molecular Weight: 545.542

Synonyms:AMG 8163

Chemical Property of AMG 8163

Chemical Property:

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Technology Process of AMG 8163

There total 1 articles about AMG 8163 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

tert-butyl 2-(6-chloropyrimidin-4-yl)-5-(trifluoromethyl)phenylcarbamate (659731-56-3) + N-(4-hydroxybenzo[d]thiazol-2-yl)acetamide (20600-52-6) → AMG 8163 (659731-59-6)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.bmcl.2008.07.112

Reference yield: 100.0%

AMG 8163 (659731-59-6) → N-(4-(6-(2-amino-4-(trifluoromethyl)phenyl)pyrimidin-4-yloxy)-benzo[d]thiazol-2-yl)acetamide (659731-60-9)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1021/jm7014638

upstream raw materials:

tert-butyl 2-(6-chloropyrimidin-4-yl)-5-(trifluoromethyl)phenylcarbamate

N-(4-hydroxybenzo[d]thiazol-2-yl)acetamide

Downstream raw materials:

N-(4-(6-(2-amino-4-(trifluoromethyl)phenyl)pyrimidin-4-yloxy)-benzo[d]thiazol-2-yl)acetamide

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