diethyl N-<4--N-prop-2-ynylamino>-2-fluorobenzoyl>-L-glutamate

Base Information

Chemical Name:diethyl N-<4--N-prop-2-ynylamino>-2-fluorobenzoyl>-L-glutamate
CAS No.:129175-36-6
Molecular Formula:C₂₉H₃₁FN₄O₆
Molecular Weight:550.587
Hs Code.:

diethyl N-<4-<N-<(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl>-N-prop-2-ynylamino>-2-fluorobenzoyl>-L-glutamate

Synonyms:diethyl N-<4--N-prop-2-ynylamino>-2-fluorobenzoyl>-L-glutamate

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Chemical Property of diethyl N-<4--N-prop-2-ynylamino>-2-fluorobenzoyl>-L-glutamate

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Technology Process of diethyl N-<4--N-prop-2-ynylamino>-2-fluorobenzoyl>-L-glutamate

There total 3 articles about diethyl N-<4--N-prop-2-ynylamino>-2-fluorobenzoyl>-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 112888-43-4
4(3H)-oxo-6-(bromomethyl)-2-methyl quinazoline

: 106585-57-3
diethyl N-(2-fluoro-4-(N-prop-2-ynylamino)benzoyl)-L-glutamate

: 129175-36-6
diethyl N-<4--N-prop-2-ynylamino>-2-fluorobenzoyl>-L-glutamate

Guidance literature:: With calcium carbonate; In N,N-dimethyl acetamide; at 50 ℃; for 24h;
DOI:10.1021/jm00173a026

Reference yield:

: 106585-55-1
diethyl N-(2-fluoro-4-nitrobenzoyl)-L-glutamate

: 129175-36-6
diethyl N-<4--N-prop-2-ynylamino>-2-fluorobenzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / H₂ / 10percent Pd/C / ethyl acetate / 4 h / 760 Torr

2: 60 percent / K₂CO₃ / dimethylformamide; toluene / 3 h / 120 °C

3: 37 percent / CaCO₃ / N,N-dimethyl-acetamide / 24 h / 50 °C

With hydrogen; potassium carbonate; calcium carbonate; palladium on activated charcoal; In N,N-dimethyl acetamide; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00173a026

Reference yield:

: 106585-56-2
diethyl N-(4-amino-2-fluorobenzoyl)-L-glutamate

: 129175-36-6
diethyl N-<4--N-prop-2-ynylamino>-2-fluorobenzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / K₂CO₃ / dimethylformamide; toluene / 3 h / 120 °C

2: 37 percent / CaCO₃ / N,N-dimethyl-acetamide / 24 h / 50 °C

With potassium carbonate; calcium carbonate; In N,N-dimethyl acetamide; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00173a026