4,5-dichloro-2-(2-fluorophenyl)-7,8-dihydrofuro<2,3-g>benzoxazole-7-methanol

Base Information

Chemical Name:4,5-dichloro-2-(2-fluorophenyl)-7,8-dihydrofuro<2,3-g>benzoxazole-7-methanol
CAS No.:136742-00-2
Molecular Formula:C₁₆H₁₀Cl₂FNO₃
Molecular Weight:354.165
Hs Code.:

Synonyms:4,5-dichloro-2-(2-fluorophenyl)-7,8-dihydrofuro<2,3-g>benzoxazole-7-methanol

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Chemical Property of 4,5-dichloro-2-(2-fluorophenyl)-7,8-dihydrofuro<2,3-g>benzoxazole-7-methanol

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Technology Process of 4,5-dichloro-2-(2-fluorophenyl)-7,8-dihydrofuro<2,3-g>benzoxazole-7-methanol

There total 5 articles about 4,5-dichloro-2-(2-fluorophenyl)-7,8-dihydrofuro<2,3-g>benzoxazole-7-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 136741-99-6
4-chloro-2-(2-fluorophenyl)-7,8-dihydrofuro<2,3-g>benzoxazole-7-methanol

: 136742-00-2
4,5-dichloro-2-(2-fluorophenyl)-7,8-dihydrofuro<2,3-g>benzoxazole-7-methanol

Guidance literature:: With sulfuryl dichloride; In dichloromethane; 1) 0-5 deg C -> r.t., 3h 2) r.t., 3h;
DOI:10.1248/cpb.39.1760

Reference yield:

: 136741-94-1
4-chloro-2-(2-fluorophenyl)-6-hydroxy-benzoxazole

: 136742-00-2
4,5-dichloro-2-(2-fluorophenyl)-7,8-dihydrofuro<2,3-g>benzoxazole-7-methanol

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / K₂CO₃ / dimethylformamide / 2.5 h / 50 - 60 °C

2: 68 percent / N,N-dimethylaniline / 6 h / Heating

3: 69 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 1) r.t., 1 h 2) reflux, 1.5 h

4: 38 percent / SO₂Cl₂ / CH₂Cl₂ / 1) 0-5 deg C -> r.t., 3h 2) r.t., 3h

With sulfuryl dichloride; potassium carbonate; N,N-dimethyl-aniline; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.39.1760

Reference yield:

: 136741-65-6
4-Chloro-2-(2-fluoro-phenyl)-6-methoxy-benzooxazole

: 136742-00-2
4,5-dichloro-2-(2-fluorophenyl)-7,8-dihydrofuro<2,3-g>benzoxazole-7-methanol

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / pyridine*HCl / 7 h / 170 - 180 °C

2: 99 percent / K₂CO₃ / dimethylformamide / 2.5 h / 50 - 60 °C

3: 68 percent / N,N-dimethylaniline / 6 h / Heating

4: 69 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 1) r.t., 1 h 2) reflux, 1.5 h

5: 38 percent / SO₂Cl₂ / CH₂Cl₂ / 1) 0-5 deg C -> r.t., 3h 2) r.t., 3h

With sulfuryl dichloride; pyridine hydrochloride; potassium carbonate; N,N-dimethyl-aniline; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.39.1760