2-hydroxyethyl 2-cyano-3-ethoxycarbonyl-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-5-carboxylate

Base Information

Chemical Name:2-hydroxyethyl 2-cyano-3-ethoxycarbonyl-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-5-carboxylate
CAS No.:75530-90-4
Molecular Formula:C₁₉H₁₉N₃O₇
Molecular Weight:401.376
Hs Code.:

Synonyms:2-hydroxyethyl 2-cyano-3-ethoxycarbonyl-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-5-carboxylate

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Chemical Property of 2-hydroxyethyl 2-cyano-3-ethoxycarbonyl-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-5-carboxylate

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Technology Process of 2-hydroxyethyl 2-cyano-3-ethoxycarbonyl-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-5-carboxylate

There total 6 articles about 2-hydroxyethyl 2-cyano-3-ethoxycarbonyl-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.1%

: 74655-19-9
2-Cyano-6-methyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 5-(2-acetoxy-ethyl) ester 3-ethyl ester

: 75530-90-4
2-hydroxyethyl 2-cyano-3-ethoxycarbonyl-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-5-carboxylate

Guidance literature:: With potassium carbonate; In ethanol; for 2h; Heating;
DOI:10.1248/cpb.40.912

Reference yield:

: 54527-68-3
2-chloroethyl acetoacetate

: 75530-90-4
2-hydroxyethyl 2-cyano-3-ethoxycarbonyl-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-5-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: 35.64 g / piperidine, AcOH / benzene / 9.5 h / Heating

2: 42.8 percent / 3 h / 100 °C

3: 68.5 percent / aq. K₂CO₃ / ethanol / 2 h / Heating

4: 96.7 percent / aq. HCl / acetone / 1.5 h / Ambient temperature

5: 1.) NH₂OH*H₂O, AcONa / 1.) AcOH, RT, 0.5 h, 2.) a) RT, 0.5 h, b) reflux, 1 h

6: 93.1 percent / aq. K₂CO₃ / ethanol / 2 h / Heating

With piperidine; hydrogenchloride; hydroxylamine; sodium acetate; potassium carbonate; acetic acid; In ethanol; acetone; benzene;
DOI:10.1248/cpb.40.912

Reference yield:

: 62760-11-6
2-chloroethyl 2-diethoxymethyl-3-ethoxycarbonyl-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-5-carboxylate

: 75530-90-4
2-hydroxyethyl 2-cyano-3-ethoxycarbonyl-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-5-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 68.5 percent / aq. K₂CO₃ / ethanol / 2 h / Heating

2: 96.7 percent / aq. HCl / acetone / 1.5 h / Ambient temperature

3: 1.) NH₂OH*H₂O, AcONa / 1.) AcOH, RT, 0.5 h, 2.) a) RT, 0.5 h, b) reflux, 1 h

4: 93.1 percent / aq. K₂CO₃ / ethanol / 2 h / Heating

With hydrogenchloride; hydroxylamine; sodium acetate; potassium carbonate; In ethanol; acetone;
DOI:10.1248/cpb.40.912