(1S,2R,3R,5R)-3-(5,7-diamino-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(hydroxymethyl)cyclopentane-1,2-diol

Base Information

Chemical Name:(1S,2R,3R,5R)-3-(5,7-diamino-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(hydroxymethyl)cyclopentane-1,2-diol
CAS No.:125073-30-5
Molecular Formula:C₁₀H₁₅N₇O₃
Molecular Weight:281.274
Hs Code.:
Mol file:125073-30-5.mol

Synonyms:1,2-Cyclopentanediol,3-(5,7-diamino-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl)-5-(hydroxymethyl)-, (1a,2a,3a,5a)- (9CI); 1,2-Cyclopentanediol,3-(5,7-diamino-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl)-5-(hydroxymethyl)-, (1a,2a,3a,5a)-(?à)-; 3H-1,2,3-Triazolo[4,5-d]pyrimidine,1,2-cyclopentanediol deriv.

Suppliers and Price of (1S,2R,3R,5R)-3-(5,7-diamino-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(hydroxymethyl)cyclopentane-1,2-diol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of (1S,2R,3R,5R)-3-(5,7-diamino-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(hydroxymethyl)cyclopentane-1,2-diol

Chemical Property:

Vapor Pressure:2.63E-22mmHg at 25°C
Boiling Point:729°C at 760 mmHg
Flash Point:394.7°C
Density:2.28g/cm³

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (1S,2R,3R,5R)-3-(5,7-diamino-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(hydroxymethyl)cyclopentane-1,2-diol

There total 4 articles about (1S,2R,3R,5R)-3-(5,7-diamino-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(hydroxymethyl)cyclopentane-1,2-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.2%

: 125073-28-1
(+/-)-(1α,2α,3α,5α)-3-(5-amino-7-chloro-3H-1,2,3-triazolo<4,5-d>pyrimidin-3-yl)-5-(hydroxymethyl)-1,2-cyclopentanediol

: 125073-30-5
(+/-)-(1α,2α,3α,5α)-3-(5,7-diamino-3H-1,2,3-triazolo<4,5-d>pyrimidin-3-yl)-5-(hydroxymethyl)-1,2-cyclopentanediol

Guidance literature:: With ammonia; at 75 ℃; for 46h;
DOI:10.1021/jm00166a020

Reference yield:

: 87419-91-8,305384-32-1,780705-82-0
(+/-)-(1α,2α,3α,5α)-3-amino-5-(hydroxymethyl)-1,2-cyclopentanediol

: 125073-30-5
(+/-)-(1α,2α,3α,5α)-3-(5,7-diamino-3H-1,2,3-triazolo<4,5-d>pyrimidin-3-yl)-5-(hydroxymethyl)-1,2-cyclopentanediol

Guidance literature:: Multi-step reaction with 5 steps

1: 74.6 percent / Et₃N / butan-1-ol / 48 h / Heating

2: 1.) conc. HCl, NaNO₂, 2.) sodium acetate, glacial acetic acid / 1.) H₂O, 0 deg C, 0.5 h, 2.) RT, 42 h

3: 68.4 percent / Zn-glacial acetic acid / H₂O; ethanol / 2.5 h / Heating

4: 79.5 percent / NaNO₂, glacial acetic acid / H₂O / 2 h / 0 °C

5: 54.2 percent / liquid ammonia / 46 h / 75 °C

With hydrogenchloride; ammonia; sodium acetate; acetic acid; triethylamine; zinc; sodium nitrite; In ethanol; water; butan-1-ol;
DOI:10.1021/jm00166a020

Reference yield:

: 125073-22-5
(+/-)-(1α,2α,3α,5α)-3-<(2-amino-6-chloro-4-pyrimidinyl)amino>-5-(hydroxymethyl)-1,2-cyclopentanediol

: 125073-30-5
(+/-)-(1α,2α,3α,5α)-3-(5,7-diamino-3H-1,2,3-triazolo<4,5-d>pyrimidin-3-yl)-5-(hydroxymethyl)-1,2-cyclopentanediol

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) conc. HCl, NaNO₂, 2.) sodium acetate, glacial acetic acid / 1.) H₂O, 0 deg C, 0.5 h, 2.) RT, 42 h

2: 68.4 percent / Zn-glacial acetic acid / H₂O; ethanol / 2.5 h / Heating

3: 79.5 percent / NaNO₂, glacial acetic acid / H₂O / 2 h / 0 °C

4: 54.2 percent / liquid ammonia / 46 h / 75 °C

With hydrogenchloride; ammonia; sodium acetate; acetic acid; zinc; sodium nitrite; In ethanol; water;
DOI:10.1021/jm00166a020