4-(o-methoxyphenyl)dehydroproline

Base Information

• Chemical Name: 4-(o-methoxyphenyl)dehydroproline
• CAS No.: 946428-44-0
• Molecular Formula: C₁₅H₁₇NO₅
• Molecular Weight: 291.304
• Mol file: 946428-44-0.mol

Synonyms:4-(o-methoxyphenyl)dehydroproline

Chemical Property of 4-(o-methoxyphenyl)dehydroproline

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-(o-methoxyphenyl)dehydroproline

There total 4 articles about 4-(o-methoxyphenyl)dehydroproline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

N-carbomethoxy-L-3-dehydroproline methyl ester + 2-methoxyphenyldiazonium tetrafluoroborate (492-95-5) → 4-(o-methoxyphenyl)dehydroproline (946428-44-0)

Guidance literature:

N-carbomethoxy-L-3-dehydroproline methyl ester; 2-methoxyphenyldiazonium tetrafluoroborate; With acetic acid; palladium diacetate; In acetonitrile; at 60 ℃; for 4h;

With 2,4-lutidine; trifluoroacetic anhydride; In toluene; Further stages.;

DOI:10.1021/ol070980t

Reference yield:

C16H21NO6 (946428-35-9) → 4-(o-methoxyphenyl)dehydroproline (946428-44-0)

Guidance literature:

With ammonium chloride; at 120 - 150 ℃;

DOI:10.1021/ol070980t

Reference yield:

N-carbomethoxy-L-3-dehydroproline methyl ester → 4-(o-methoxyphenyl)dehydroproline (946428-44-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / Pd(OAc)2 / 12 h / Heating

2: NH₄Cl / 120 - 150 °C

With ammonium chloride; palladium diacetate;

DOI:10.1021/ol070980t

upstream raw materials:

C₁₆H₂₁NO₆

2-methoxyphenyldiazonium tetrafluoroborate

Downstream raw materials:

C₂₂H₂₉NO₉

C₂₈H₃₃NO₉Se

C₂₂H₂₇NO₉

C₂₂H₂₉NO₉