(2R,3R)-2-[N-(dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propanoic acid

Base Information

• Chemical Name: (2R,3R)-2-[N-(dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propanoic acid
• CAS No.: 906366-48-1
• Molecular Formula: C₁₁H₁₀Cl₂N₂O₆
• Molecular Weight: 337.116
• Mol file: 906366-48-1.mol

Synonyms:(2R,3R)-2-[N-(dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propanoic acid

Chemical Property of (2R,3R)-2-[N-(dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3R)-2-[N-(dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propanoic acid

There total 3 articles about (2R,3R)-2-[N-(dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

chloramphenicol (7384-89-6,85666-84-8) → (2R,3R)-2-[N-(dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propanoic acid (906366-48-1) + 4-nitro-benzoic acid (62-23-7)

Guidance literature:

With sodium hypochlorite; sodium hydrogencarbonate; sodium bromide; fully methyl-modified gel SG-TEMPO-2; In acetone; at 0 ℃; for 14h; pH=9.1; Further Variations:; Catalysts; Product distribution;

DOI:10.1002/adsc.200303239

Reference yield:

(2RS,3RS)-2-amino-3-hydroxy-3-(4-nitro-phenyl)-propionic acid (5872-74-2,5872-75-3,10098-38-1,17580-62-0,28908-09-0,50730-77-3,110772-43-5,119934-01-9,129446-45-3,135635-69-7) → (2R,3R)-2-[N-(dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propanoic acid (906366-48-1)

Guidance literature:

Multi-step reaction with 2 steps

2: enzyme-substance from pseudomonas spec.

With enzyme-substance from pseudomonas spec;

Reference yield:

(2RS,3RS)-2-(2,2-dichloro-acetylamino)-3-hydroxy-3-(4-nitro-phenyl)-propionic acid → DANP (200012-06-2) + (2R,3R)-2-[N-(dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propanoic acid (906366-48-1)

Guidance literature:

With enzyme-substance from pseudomonas spec;

upstream raw materials:

chloramphenicol

(2RS,3RS)-2-amino-3-hydroxy-3-(4-nitro-phenyl)-propionic acid