3-[3-(2-methoxycarbonyl-2-prop-2-ynyloxycarbonylamino-ethyl)-phenyl]-2-prop-2-ynyloxycarbonylaminopropionic acid methyl ester

Base Information

Chemical Name:3-[3-(2-methoxycarbonyl-2-prop-2-ynyloxycarbonylamino-ethyl)-phenyl]-2-prop-2-ynyloxycarbonylaminopropionic acid methyl ester
CAS No.:904704-08-1
Molecular Formula:C₂₂H₂₄N₂O₈
Molecular Weight:444.441
Hs Code.:

Synonyms:3-[3-(2-methoxycarbonyl-2-prop-2-ynyloxycarbonylamino-ethyl)-phenyl]-2-prop-2-ynyloxycarbonylaminopropionic acid methyl ester

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Chemical Property of 3-[3-(2-methoxycarbonyl-2-prop-2-ynyloxycarbonylamino-ethyl)-phenyl]-2-prop-2-ynyloxycarbonylaminopropionic acid methyl ester

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Technology Process of 3-[3-(2-methoxycarbonyl-2-prop-2-ynyloxycarbonylamino-ethyl)-phenyl]-2-prop-2-ynyloxycarbonylaminopropionic acid methyl ester

There total 3 articles about 3-[3-(2-methoxycarbonyl-2-prop-2-ynyloxycarbonylamino-ethyl)-phenyl]-2-prop-2-ynyloxycarbonylaminopropionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 2-amino-3-[3-(2-amino-2-methoxycarbonyl-ethyl)-phenyl]-propionic acid methyl ester

: 35718-08-2
propargyl chloroformate

: 904704-08-1
3-[3-(2-methoxycarbonyl-2-prop-2-ynyloxycarbonylamino-ethyl)-phenyl]-2-prop-2-ynyloxycarbonylaminopropionic acid methyl ester

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; for 48h;
DOI:10.1016/j.carres.2006.04.028

Reference yield:

: 904704-06-9
2-benzyloxycarbonylamino-3-[3-(2-benzyloxycarbonylamino-2-methoxycarbonyl-ethyl)-phenyl]-propionic acid methyl ester

: 904704-08-1
3-[3-(2-methoxycarbonyl-2-prop-2-ynyloxycarbonylamino-ethyl)-phenyl]-2-prop-2-ynyloxycarbonylaminopropionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / Pd/C / methanol / 20 °C / 760 Torr

2: 38 percent / DMAP; Et₃N / CH₂Cl₂ / 48 h / 20 °C

With dmap; hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1016/j.carres.2006.04.028

Reference yield:

: 89525-20-2
2-benzyloxycarbonylamino-3-[3-(2-benzyloxycarbonylamino-2-methoxycarbonyl-vinyl)-phenyl]-acrylic acid methyl ester

: 904704-08-1
3-[3-(2-methoxycarbonyl-2-prop-2-ynyloxycarbonylamino-ethyl)-phenyl]-2-prop-2-ynyloxycarbonylaminopropionic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / hydrogen / Wilkinson's catalyst / ethanol / 120 h / 20 °C / 3102.89 Torr

2: hydrogen / Pd/C / methanol / 20 °C / 760 Torr

3: 38 percent / DMAP; Et₃N / CH₂Cl₂ / 48 h / 20 °C

With dmap; hydrogen; triethylamine; palladium on activated charcoal; Wilkinson's catalyst; In methanol; ethanol; dichloromethane;
DOI:10.1016/j.carres.2006.04.028