N′-(3-cyano-4-morpholino-5-phenylthiophen-2-yl)-N,N-dimethylformimidamide

Base Information

Chemical Name:N′-(3-cyano-4-morpholino-5-phenylthiophen-2-yl)-N,N-dimethylformimidamide
CAS No.:1429012-21-4
Molecular Formula:C₁₈H₂₀N₄OS
Molecular Weight:340.449
Hs Code.:

Synonyms:N′-(3-cyano-4-morpholino-5-phenylthiophen-2-yl)-N,N-dimethylformimidamide

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Chemical Property of N′-(3-cyano-4-morpholino-5-phenylthiophen-2-yl)-N,N-dimethylformimidamide

Chemical Property:

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Technology Process of N′-(3-cyano-4-morpholino-5-phenylthiophen-2-yl)-N,N-dimethylformimidamide

There total 1 articles about N′-(3-cyano-4-morpholino-5-phenylthiophen-2-yl)-N,N-dimethylformimidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1429012-11-2
N′-(3-cyano-5-phenyl-4-(trimethylsilyl)thiophen-2-yl)-N,N-dimethylformimidamide

: 1429012-21-4
N′-(3-cyano-4-morpholino-5-phenylthiophen-2-yl)-N,N-dimethylformimidamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: silver trifluoroacetate / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

1.2: 4 h / -78 °C / Inert atmosphere; Darkness

2.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene / toluene / 36 h / 100 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; silver trifluoroacetate; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; In tetrahydrofuran; toluene; 2.1: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.bmc.2013.02.006

Reference yield: 50.0%

: 1429012-21-4
N′-(3-cyano-4-morpholino-5-phenylthiophen-2-yl)-N,N-dimethylformimidamide

: 1429012-31-6
5-morpholino-6-phenylthieno[2,3-d]pyrimidin-4-amine

Guidance literature:: With formamide; at 130 ℃; for 48h; Inert atmosphere;
DOI:10.1016/j.bmc.2013.02.006

Reference yield:

: 1429012-21-4
N′-(3-cyano-4-morpholino-5-phenylthiophen-2-yl)-N,N-dimethylformimidamide

: C₂₅H₃₆N₄O₇P₂S

Guidance literature:: Multi-step reaction with 2 steps

1: formamide / 48 h / 130 °C / Inert atmosphere

2: toluene / 48 h / 130 °C / Inert atmosphere; Sealed tube; Darkness

With formamide; In toluene;
DOI:10.1016/j.bmc.2013.02.006