Technology Process of 3'-(benzyloxy)-6'-<<β-(trimethylsilyl)ethoxy>carbonyl>-5'-(1-heptyn-1-yl)phenyl 3-O-benzyl-5,6-cyclopentylidene-D-galactofuranoside
There total 14 articles about 3'-(benzyloxy)-6'-<<β-(trimethylsilyl)ethoxy>carbonyl>-5'-(1-heptyn-1-yl)phenyl 3-O-benzyl-5,6-cyclopentylidene-D-galactofuranoside which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 87 percent / bis(triphenylphosphine)palladium(II) chloride, Et3N / dimethylformamide / 12 h / 90 °C
2: 48percent aq. KOH / dimethylsulfoxide / 0.5 h / 60 °C
3: 254 mg / 4-DMAP, EDCI / CH2Cl2 / 5 h / Ambient temperature
4: K2CO3, 18-crown-6 / acetone / 8 h / Heating
With
dmap; potassium hydroxide; bis(triphenylphosphine)palladium(II)-chloride; 18-crown-6 ether; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ja00028a035
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 254 mg / 4-DMAP, EDCI / CH2Cl2 / 5 h / Ambient temperature
2: K2CO3, 18-crown-6 / acetone / 8 h / Heating
With
dmap; 18-crown-6 ether; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
dichloromethane; acetone;
DOI:10.1021/ja00028a035
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 34 percent / trifluoroacetic anhydride / trifluoroacetic acid / 24 h / Ambient temperature
2: 92 percent / triphenylphosphine, DIAD / tetrahydrofuran / 2 h / 0 - 20 °C
3: 85 percent / pyridine / 12 h / 0 °C
4: 87 percent / bis(triphenylphosphine)palladium(II) chloride, Et3N / dimethylformamide / 12 h / 90 °C
5: 48percent aq. KOH / dimethylsulfoxide / 0.5 h / 60 °C
6: 254 mg / 4-DMAP, EDCI / CH2Cl2 / 5 h / Ambient temperature
7: K2CO3, 18-crown-6 / acetone / 8 h / Heating
With
pyridine; dmap; potassium hydroxide; bis(triphenylphosphine)palladium(II)-chloride; 18-crown-6 ether; di-isopropyl azodicarboxylate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; trifluoroacetic anhydride;
In
tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; trifluoroacetic acid;
DOI:10.1021/ja00028a035