Chemical Property of penitrem A
Chemical Property:
- Melting Point:238°C
- Refractive Index:1.698
- Boiling Point:°Cat760mmHg
- PKA:13.22±0.70(Predicted)
- Flash Point:°C
- PSA：107.47000
- Density:1.44 g/cm3
- LogP:5.66170
- Storage Temp.:2-8°C
- Solubility.:Soluble in DMSO (up to 6 mg/ml)
- XLogP3:3.8
- Hydrogen Bond Donor Count:4
- Hydrogen Bond Acceptor Count:6
- Rotatable Bond Count:1
- Exact Mass:633.2857158
- Heavy Atom Count:45
- Complexity:1420
- Purity/Quality:
-
98%,99%, *data from raw suppliers
Penitrem A *data from reagent suppliers
Safty Information:
- Pictogram(s):
T+
- Hazard Codes:T+,T
- Statements:
26/27/28
- Safety Statements:
36/37/39-45
- MSDS Files:
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SDS file from LookChem
Total 1 MSDS from other Authors
Useful:
- Chemical Classes:Biological Agents -> Mycotoxins
- Canonical SMILES:CC(=C)C1C(C2C3(O2)C(O1)CCC4(C3(CCC5C4(C6=C7C5OC(C8CC9C8(C1=C7C(=CC(=C1CC9=C)Cl)N6)O)(C)C)C)O)C)O
- Isomeric SMILES:CC(=C)[C@@H]1[C@@H]([C@@H]2[C@@]3(O2)[C@@H](O1)CC[C@]4([C@]3(CC[C@@H]5[C@@]4(C6=C7[C@H]5OC([C@H]8C[C@H]9[C@@]8(C1=C7C(=CC(=C1CC9=C)Cl)N6)O)(C)C)C)O)C)O
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Description
Penitrem A (12627-35-9) is a fungal mycotoxin that acts as a selective, irreversible blocker of the smooth muscle high conductance Ca2+-activated K+?(BK, KCa1.1) channel (100% block at 10 nM).1?Displays brain neurotoxicity in rats along with dose-dependent convulsions and death.2?An important tool for studying the role of BK channels in vascular function which is effective in cellular, tissue and?in vivo?experiments.3?Inhibits BK channels in inside-out and cell-attached patches, whereas iberiotoxin (considered the gold standard BK channel blocker) does not.3?May be used to partially ablate Purkinje cells in immature rat cerebellum providing a model for neural stem cell transplantation studies.4
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Uses
Penitrem A is a tremorgenic mycotoxin isolated from Penicillium species. Penitrem A is a selective blocker of high-conductance Ca2+-activated potassium channels. Penitrem A has been used as Ca2+-Activated K+ (BK) channel blocker to study its effect on BK current in bag cell neurons.
