acetic acid 6-acetylamino-8-(2-nitro-benzenesulfonylamino)-pyrrolo[4,3,2-de]quinolin-4-ylmethyl ester

Base Information

Chemical Name:acetic acid 6-acetylamino-8-(2-nitro-benzenesulfonylamino)-pyrrolo[4,3,2-de]quinolin-4-ylmethyl ester
CAS No.:689225-48-7
Molecular Formula:C₂₁H₁₇N₅O₇S
Molecular Weight:483.461
Hs Code.:

acetic acid 6-acetylamino-8-(2-nitro-benzenesulfonylamino)-pyrrolo[4,3,2-<i>de</i>]quinolin-4-ylmethyl ester

Synonyms:acetic acid 6-acetylamino-8-(2-nitro-benzenesulfonylamino)-pyrrolo[4,3,2-de]quinolin-4-ylmethyl ester

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Chemical Property of acetic acid 6-acetylamino-8-(2-nitro-benzenesulfonylamino)-pyrrolo[4,3,2-de]quinolin-4-ylmethyl ester

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Technology Process of acetic acid 6-acetylamino-8-(2-nitro-benzenesulfonylamino)-pyrrolo[4,3,2-de]quinolin-4-ylmethyl ester

There total 10 articles about acetic acid 6-acetylamino-8-(2-nitro-benzenesulfonylamino)-pyrrolo[4,3,2-de]quinolin-4-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1694-92-4
2-Nitrobenzenesulfonyl chloride

: 689225-47-6
acetic acid 6-acetylamino-8-azido-pyrrolo[4,3,2-de]quinolin-4-ylmethyl ester

: 689225-48-7
acetic acid 6-acetylamino-8-(2-nitro-benzenesulfonylamino)-pyrrolo[4,3,2-de]quinolin-4-ylmethyl ester

Guidance literature:: acetic acid 6-acetylamino-8-azido-pyrrolo[4,3,2-de]quinolin-4-ylmethyl ester; With hydrogen; Lindlar's catalyst; In ethanol; at 20 ℃; for 2h;

2-Nitrobenzenesulfonyl chloride; With pyridine; In 1,2-dichloro-ethane; at 50 ℃; for 1h; Further stages.;
DOI:10.1016/j.tetlet.2004.01.140

Reference yield:

: 2717-76-2,130812-44-1,130812-46-3
(S)-N-benzyloxycarbonyl-L-tryptophan methyl ester

: 689225-48-7
acetic acid 6-acetylamino-8-(2-nitro-benzenesulfonylamino)-pyrrolo[4,3,2-de]quinolin-4-ylmethyl ester

Guidance literature:: Multi-step reaction with 10 steps

1.1: LiBH₄ / tetrahydrofuran / 1 h / Heating

1.2: 95 percent / DDQ / tetrahydrofuran; H₂O / 1 h / 20 °C

2.1: Tl(OCOCF₃)3 / trifluoroacetic acid / 1 h / 20 °C

2.2: 59 percent / CuSO₄*5H₂O / dimethylformamide / 0.17 h / 130 °C

3.1: 85 percent / NaBH₃CN; BF₃*Et₂O / tetrahydrofuran / 4 h / 20 °C

4.1: 82 percent / NO(SO₃K)2 / acetone; aq. phosphate buffer / 2 h / 20 °C / pH 7

5.1: 79 percent / air / benzene / 4 h / 20 °C

6.1: 100 percent / H₂ / Pd/C / ethanol / 2 h / 20 °C

7.1: air / dimethylformamide / 1 h / 70 °C

8.1: dimethylformamide / 12 h / 20 °C

9.1: Tf₂O; pyridine / CH₂Cl₂ / 1 h / -78 °C

9.2: 68 percent / n-Bu₄NN₃ / CH₂Cl₂ / 12 h / -78 - 20 °C

10.1: H₂ / Lindlar catalyst / ethanol / 2 h / 20 °C

10.2: 75 percent / pyridine / 1,2-dichloro-ethane / 1 h / 50 °C

With pyridine; lithium borohydride; air; potassium nitrososulfonate; trifluoromethylsulfonic anhydride; boron trifluoride diethyl etherate; hydrogen; sodium cyanoborohydride; thallium(III) trifluoroacetate; palladium on activated charcoal; Lindlar's catalyst; In tetrahydrofuran; phosphate buffer; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone; trifluoroacetic acid; benzene;
DOI:10.1016/j.tetlet.2004.01.140

Reference yield:

: 689225-45-4
6-amino-4-hydroxymethyl-1H-pyrrolo[4,3,2-de]quinolin-8-one

: 689225-48-7
acetic acid 6-acetylamino-8-(2-nitro-benzenesulfonylamino)-pyrrolo[4,3,2-de]quinolin-4-ylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: dimethylformamide / 12 h / 20 °C

2.1: Tf₂O; pyridine / CH₂Cl₂ / 1 h / -78 °C

2.2: 68 percent / n-Bu₄NN₃ / CH₂Cl₂ / 12 h / -78 - 20 °C

3.1: H₂ / Lindlar catalyst / ethanol / 2 h / 20 °C

3.2: 75 percent / pyridine / 1,2-dichloro-ethane / 1 h / 50 °C

With pyridine; trifluoromethylsulfonic anhydride; hydrogen; Lindlar's catalyst; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2004.01.140