C₃₃H₄₃F₃O₆SSi₂

Base Information

Chemical Name:C₃₃H₄₃F₃O₆SSi₂
CAS No.:1431879-88-7
Molecular Formula:C₃₃H₄₃F₃O₆SSi₂
Molecular Weight:680.933
Hs Code.:

C<sub>33</sub>H<sub>43</sub>F<sub>3</sub>O<sub>6</sub>SSi<sub>2</sub>

Synonyms:C₃₃H₄₃F₃O₆SSi₂

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Chemical Property of C₃₃H₄₃F₃O₆SSi₂

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Technology Process of C₃₃H₄₃F₃O₆SSi₂

There total 11 articles about C₃₃H₄₃F₃O₆SSi₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1431879-76-3
(2R,6R)-2-((E)-5-((tert-butyldiphenylsilyl)oxy)pent-1-en-1-yl)-6-methoxy-6-((trimethylsilyl)ethynyl)dihydro-2H-pyran-3(4H)-one

: 145100-51-2
N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulphonyl]methanesulphonamide

: 1431879-88-7
C₃₃H₄₃F₃O₆SSi₂

Guidance literature:: With potassium hexamethylsilazane; In tetrahydrofuran; at -78 ℃; for 0.166667h; Inert atmosphere;
DOI:10.1021/ol400487e

Reference yield:

: 1431879-69-4
(4S)-4-((4R)-2,2-dimethyl-1,3-dioxolan-4-yl)-4-((4-methoxybenzyl)oxy)butan-1-ol

: 1431879-88-7
C₃₃H₄₃F₃O₆SSi₂

Guidance literature:: Multi-step reaction with 10 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 - -60 °C / Inert atmosphere

1.2: 0.33 h / -60 - 0 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 °C / Inert atmosphere

3.1: triethylamine; sulfur trioxide pyridine complex / dichloromethane; dimethyl sulfoxide / 2 h / 0 °C / Inert atmosphere

4.1: toluene-4-sulfonic acid / methanol / 2 h / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine; sulfur trioxide pyridine complex / dichloromethane; dimethyl sulfoxide / 0.08 h / 0 °C / Inert atmosphere

6.1: chromium dichloride / tetrahydrofuran; 1,4-dioxane / 12 h / 0 - 20 °C / Inert atmosphere

7.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

7.2: 0.5 h / 20 °C / Inert atmosphere

7.3: 0.08 h / Inert atmosphere

8.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane; tert-butyl alcohol / 0.17 h / 20 °C / pH 7 / Inert atmosphere

9.1: N-ethyl-N,N-diisopropylamine; sulfur trioxide pyridine complex / dichloromethane; dimethyl sulfoxide / 0.17 h / 0 °C / Inert atmosphere

10.1: potassium hexamethylsilazane / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere

With chromium dichloride; n-butyllithium; oxalyl dichloride; sulfur trioxide pyridine complex; potassium hexamethylsilazane; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; 9-bora-bicyclo[3.3.1]nonane; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; dimethyl sulfoxide; tert-butyl alcohol; 1.1: |Swern Oxidation / 1.2: |Swern Oxidation / 5.1: |Parikh-Doering Oxidation / 6.1: |Takai-Utimoto Olefination;
DOI:10.1021/ol400487e

Reference yield:

: (R)-4-((S)-1-((4-methoxybenzyl)oxy)but-3-en-1-yl)-2,2-dimethyl-1,3-dioxolane

: 1431879-88-7
C₃₃H₄₃F₃O₆SSi₂

Guidance literature:: Multi-step reaction with 11 steps

1.1: borane / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

1.2: 2 h / 0 - 20 °C / Inert atmosphere

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 - -60 °C / Inert atmosphere

2.2: 0.33 h / -60 - 0 °C / Inert atmosphere

3.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

3.2: 1 h / -78 °C / Inert atmosphere

4.1: triethylamine; sulfur trioxide pyridine complex / dichloromethane; dimethyl sulfoxide / 2 h / 0 °C / Inert atmosphere

5.1: toluene-4-sulfonic acid / methanol / 2 h / Inert atmosphere

6.1: N-ethyl-N,N-diisopropylamine; sulfur trioxide pyridine complex / dichloromethane; dimethyl sulfoxide / 0.08 h / 0 °C / Inert atmosphere

7.1: chromium dichloride / tetrahydrofuran; 1,4-dioxane / 12 h / 0 - 20 °C / Inert atmosphere

8.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

8.2: 0.5 h / 20 °C / Inert atmosphere

8.3: 0.08 h / Inert atmosphere

9.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane; tert-butyl alcohol / 0.17 h / 20 °C / pH 7 / Inert atmosphere

10.1: N-ethyl-N,N-diisopropylamine; sulfur trioxide pyridine complex / dichloromethane; dimethyl sulfoxide / 0.17 h / 0 °C / Inert atmosphere

11.1: potassium hexamethylsilazane / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere

With chromium dichloride; n-butyllithium; oxalyl dichloride; borane; sulfur trioxide pyridine complex; potassium hexamethylsilazane; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; 9-bora-bicyclo[3.3.1]nonane; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; dimethyl sulfoxide; tert-butyl alcohol; 2.1: |Swern Oxidation / 2.2: |Swern Oxidation / 6.1: |Parikh-Doering Oxidation / 7.1: |Takai-Utimoto Olefination;
DOI:10.1021/ol400487e