Technology Process of (3R,7S)-3-Benzyloxy-5-methylene-7-triisopropylsilanyloxy-dec-9-enal
There total 11 articles about (3R,7S)-3-Benzyloxy-5-methylene-7-triisopropylsilanyloxy-dec-9-enal which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 91 percent / 1-(2,4,6-triisopropylbenzenesulfonyl)imidazole, NaH
2: 89 percent / TsOH / CH2Cl2
3: 93 percent / K2CO3 / methanol
4: 1.) Me3SnCuLiBr; 2.) MeLi; 3.) lithium 2-thienylcyanocuprate / 1.) THF, -78 deg C
5: KH / tetrahydrofuran
6: TsOH / methanol
7: imidazole
8: DDQ
9: Swern oxidn.
With
1H-imidazole; Me3SnCu*LiBr; Swern oxidn; methyllithium; potassium hydride; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; thien-2-yl(cyano)copper lithium; 2,3-dicyano-5,6-dichloro-p-benzoquinone; 1-[(2,4,6-triisopropylphenyl)sulfonyl]-1H-imidazole;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0040-4039(98)00686-8
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 1.) CuI; 2.) TsOH / 2.) MeOH
2: 91 percent / 1-(2,4,6-triisopropylbenzenesulfonyl)imidazole, NaH
3: 89 percent / TsOH / CH2Cl2
4: 93 percent / K2CO3 / methanol
5: 1.) Me3SnCuLiBr; 2.) MeLi; 3.) lithium 2-thienylcyanocuprate / 1.) THF, -78 deg C
6: KH / tetrahydrofuran
7: TsOH / methanol
8: imidazole
9: DDQ
10: Swern oxidn.
With
1H-imidazole; copper(l) iodide; Me3SnCu*LiBr; Swern oxidn; methyllithium; potassium hydride; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; thien-2-yl(cyano)copper lithium; 2,3-dicyano-5,6-dichloro-p-benzoquinone; 1-[(2,4,6-triisopropylphenyl)sulfonyl]-1H-imidazole;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0040-4039(98)00686-8
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 82 percent / aq. AcOH
2: 91 percent / 1-(2,4,6-triisopropylbenzenesulfonyl)imidazole, NaH
3: 89 percent / TsOH / CH2Cl2
4: 93 percent / K2CO3 / methanol
5: 1.) Me3SnCuLiBr; 2.) MeLi; 3.) lithium 2-thienylcyanocuprate / 1.) THF, -78 deg C
6: KH / tetrahydrofuran
7: TsOH / methanol
8: imidazole
9: DDQ
10: Swern oxidn.
With
1H-imidazole; Me3SnCu*LiBr; Swern oxidn; methyllithium; potassium hydride; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; acetic acid; thien-2-yl(cyano)copper lithium; 2,3-dicyano-5,6-dichloro-p-benzoquinone; 1-[(2,4,6-triisopropylphenyl)sulfonyl]-1H-imidazole;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0040-4039(98)00686-8
