Technology Process of 7,8-bis(benzyloxy)-2,2-dimethyl-4H-1,3-benzodioxin-6-ol
There total 8 articles about 7,8-bis(benzyloxy)-2,2-dimethyl-4H-1,3-benzodioxin-6-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
7,8-bis(benzyloxy)-6-bromo-2,2-dimethyl-4H-1,3-benzodioxine;
With
n-butyllithium;
In
diethyl ether; hexane;
at -78 ℃;
for 2h;
With
Trimethyl borate;
In
diethyl ether; hexane;
at -78 - 0 ℃;
for 0.5h;
DOI:10.1021/ja040037+
- Guidance literature:
-
With
sodium hydroxide; dihydrogen peroxide;
In
diethyl ether; water;
at 0 ℃;
for 0.5h;
DOI:10.1002/anie.200351805
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 85 percent / K2CO3; KI / dimethylformamide / 24 h / 0 - 25 °C
2.1: 83 percent / MgBr2*Et2O / diethyl ether / 10 h / 25 °C
3.1: 89 percent / Br2; sodium acetate / acetic acid / 2 h / 25 °C
4.1: 91 percent / NaBH4 / ethanol / 0.5 h / 0 - 25 °C
5.1: 95 percent / p-toluenesulfonic acid / CH2Cl2 / 1 h
6.1: n-BuLi / diethyl ether; hexane / 2 h / -78 °C
6.2: 90 percent / B(OMe)3 / diethyl ether; hexane / 0.5 h / -78 - 0 °C
With
sodium tetrahydroborate; n-butyllithium; bromine; sodium acetate; potassium carbonate; toluene-4-sulfonic acid; potassium iodide; magnesium bromide;
In
diethyl ether; ethanol; hexane; dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/ja040037+
