2-(3-(4-(1H-indazol-5-ylamino)quinazolin-2-yl)phenoxy)-N-(cyclopropylmethyl)acetamide

Base Information

Chemical Name:2-(3-(4-(1H-indazol-5-ylamino)quinazolin-2-yl)phenoxy)-N-(cyclopropylmethyl)acetamide
CAS No.:911417-76-0
Molecular Formula:C₂₇H₂₄N₆O₂
Molecular Weight:464.527
Hs Code.:

Synonyms:2-(3-(4-(1H-indazol-5-ylamino)quinazolin-2-yl)phenoxy)-N-(cyclopropylmethyl)acetamide

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Chemical Property of 2-(3-(4-(1H-indazol-5-ylamino)quinazolin-2-yl)phenoxy)-N-(cyclopropylmethyl)acetamide

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Technology Process of 2-(3-(4-(1H-indazol-5-ylamino)quinazolin-2-yl)phenoxy)-N-(cyclopropylmethyl)acetamide

There total 9 articles about 2-(3-(4-(1H-indazol-5-ylamino)quinazolin-2-yl)phenoxy)-N-(cyclopropylmethyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 911417-62-4
2-(3-(4-(1H-indazol-5-ylamino)quinazolin-2-yl)phenoxy)acetic acid

: 2516-47-4
cyclopropanemethylamine

: 911417-76-0
2-(3-(4-(1H-indazol-5-ylamino)quinazolin-2-yl)phenoxy)-N-(cyclopropylmethyl)acetamide

Guidance literature:: 2-(3-(4-(1H-indazol-5-ylamino)quinazolin-2-yl)phenoxy)acetic acid; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.25h;

cyclopropanemethylamine; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 1.25h;

Reference yield:

: 28144-70-9,88-68-6
anthranilic acid amide

: 911417-76-0
2-(3-(4-(1H-indazol-5-ylamino)quinazolin-2-yl)phenoxy)-N-(cyclopropylmethyl)acetamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: pyridine / chloroform / 6 h / 20 °C

2.1: sodium hydroxide / water / 4 h / Heating / reflux

2.2: 2 h / 20 °C / pH 7

3.1: boron tribromide / dichloromethane / 4 h / -78 - 20 °C

3.2: 0.5 h / -78 - 20 °C

3.3: pH 7

4.1: pyridine / 3.5 h / 105 °C

5.1: thionyl chloride; N,N-dimethyl-formamide / 4 h / Heating / reflux

6.1: isopropyl alcohol / 0.5 h / 95 °C

7.1: methanol; ammonia; water / 48 h / 20 °C

8.1: potassium carbonate / N,N-dimethyl-formamide / 3.5 h / 80 °C

9.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

10.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 0.25 h / 20 °C

10.2: 0.5 h / 20 °C

With pyridine; methanol; sodium hydroxide; thionyl chloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; ammonia; water; boron tribromide; potassium carbonate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; trifluoroacetic acid; In dichloromethane; chloroform; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 371947-93-2
3-(4-oxo-3,4-dihydroquinazolin-2-yl)phenyl acetate

: 911417-76-0
2-(3-(4-(1H-indazol-5-ylamino)quinazolin-2-yl)phenoxy)-N-(cyclopropylmethyl)acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride; N,N-dimethyl-formamide / 4 h / Heating / reflux

2.1: isopropyl alcohol / 0.5 h / 95 °C

3.1: methanol; ammonia; water / 48 h / 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 3.5 h / 80 °C

5.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

6.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 0.25 h / 20 °C

6.2: 0.5 h / 20 °C

With methanol; thionyl chloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; ammonia; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;