Technology Process of (6R,S)-11-deaza-10-methyltetrahydrohomofolate
There total 11 articles about (6R,S)-11-deaza-10-methyltetrahydrohomofolate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 56 percent / CH2Cl2 / 40 h / Ambient temperature
2: 41 percent / CuBr / tetrahydrofuran / a) -25 deg C, 2 h, b) r.t., 12 h
3: 99 percent / hydroxylamine hydrochloride, pyridine / methanol / 1 h / Heating
4: 83 percent / hydrazine / methanol / 48 h
5: 75 percent / methylmorpholine / methanol / 3 h / Heating
6: 1N HCl, TFA / 60 °C
8: 50 percent / N-methylmorpholine, isobutyl chloroformate / dimethylformamide; dimethylsulfoxide / 18 h / solid phase coupling
9: H2 / PtO2 / 14 h / 760 Torr / pH 7.0
With
4-methyl-morpholine; 2-methylmorpholine; pyridine; hydrogenchloride; hydroxylamine hydrochloride; hydrogen; trifluoroacetic acid; copper(I) bromide; hydrazine; isobutyl chloroformate;
platinum(IV) oxide;
In
tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm00126a022
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 75 percent / methylmorpholine / methanol / 3 h / Heating
2: 1N HCl, TFA / 60 °C
4: 50 percent / N-methylmorpholine, isobutyl chloroformate / dimethylformamide; dimethylsulfoxide / 18 h / solid phase coupling
5: H2 / PtO2 / 14 h / 760 Torr / pH 7.0
With
4-methyl-morpholine; 2-methylmorpholine; hydrogenchloride; hydrogen; trifluoroacetic acid; isobutyl chloroformate;
platinum(IV) oxide;
In
methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm00126a022
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 50 percent / N-methylmorpholine, isobutyl chloroformate / dimethylformamide; dimethylsulfoxide / 18 h / solid phase coupling
2: H2 / PtO2 / 14 h / 760 Torr / pH 7.0
With
4-methyl-morpholine; hydrogen; isobutyl chloroformate;
platinum(IV) oxide;
In
dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm00126a022
