N-(7-chloro-6-fluorobenzo[d]thiazol-2-yl)-3-(4-dimethylamino)phenylacrylamide

Base Information

Chemical Name:N-(7-chloro-6-fluorobenzo[d]thiazol-2-yl)-3-(4-dimethylamino)phenylacrylamide
CAS No.:1311166-13-8
Molecular Formula:C₁₈H₁₅ClFN₃OS
Molecular Weight:375.854
Hs Code.:

Synonyms:N-(7-chloro-6-fluorobenzo[d]thiazol-2-yl)-3-(4-dimethylamino)phenylacrylamide

Suppliers and Price of N-(7-chloro-6-fluorobenzo[d]thiazol-2-yl)-3-(4-dimethylamino)phenylacrylamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of N-(7-chloro-6-fluorobenzo[d]thiazol-2-yl)-3-(4-dimethylamino)phenylacrylamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-(7-chloro-6-fluorobenzo[d]thiazol-2-yl)-3-(4-dimethylamino)phenylacrylamide

There total 3 articles about N-(7-chloro-6-fluorobenzo[d]thiazol-2-yl)-3-(4-dimethylamino)phenylacrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1269791-34-5
N-(7-chloro-6-fluorobenzo[d]thiazol-2-yl)acetamide

: 100-10-7
4-dimethylamino-benzaldehyde

: 1311166-13-8
N-(7-chloro-6-fluorobenzo[d]thiazol-2-yl)-3-(4-dimethylamino)phenylacrylamide

Guidance literature:: With sodium hydroxide; In ethanol; at 20 ℃;
DOI:10.1002/ardp.201100072

Reference yield:

: 101337-93-3
2-amino-6-fluoro-7-chloro-1,3-benzothiazole

: 1311166-13-8
N-(7-chloro-6-fluorobenzo[d]thiazol-2-yl)-3-(4-dimethylamino)phenylacrylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1 h / Reflux

2: sodium hydroxide / ethanol / 20 °C

With sodium hydroxide; In ethanol; 2: Claisen Schmidt condensation;
DOI:10.1002/ardp.201100072

Reference yield:

: 367-21-5
3-chloro-4-fluorophenylamine

: 1311166-13-8
N-(7-chloro-6-fluorobenzo[d]thiazol-2-yl)-3-(4-dimethylamino)phenylacrylamide

Guidance literature:: Multi-step reaction with 3 steps

1: bromine; acetic acid / 14 h / 5 - 20 °C

2: 1 h / Reflux

3: sodium hydroxide / ethanol / 20 °C

With bromine; acetic acid; sodium hydroxide; In ethanol; 3: Claisen Schmidt condensation;
DOI:10.1002/ardp.201100072