N-[3-[3-[5-[[1-(tert-butoxycarbonyl)-2(S)-azetidinyl]methoxy]-3-pyridyl]phenyl]propyl]acetamide

Base Information

Chemical Name:N-[3-[3-[5-[[1-(tert-butoxycarbonyl)-2(S)-azetidinyl]methoxy]-3-pyridyl]phenyl]propyl]acetamide
CAS No.:1222138-70-6
Molecular Formula:C₂₅H₃₃N₃O₄
Molecular Weight:439.555
Hs Code.:

Synonyms:N-[3-[3-[5-[[1-(tert-butoxycarbonyl)-2(S)-azetidinyl]methoxy]-3-pyridyl]phenyl]propyl]acetamide

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Chemical Property of N-[3-[3-[5-[[1-(tert-butoxycarbonyl)-2(S)-azetidinyl]methoxy]-3-pyridyl]phenyl]propyl]acetamide

Chemical Property:

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Technology Process of N-[3-[3-[5-[[1-(tert-butoxycarbonyl)-2(S)-azetidinyl]methoxy]-3-pyridyl]phenyl]propyl]acetamide

There total 6 articles about N-[3-[3-[5-[[1-(tert-butoxycarbonyl)-2(S)-azetidinyl]methoxy]-3-pyridyl]phenyl]propyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1222138-60-4
3-[3-[5-[[1-(tert-butoxycarbonyl)-2(S)-azetidinyl]methoxy]-3-pyridyl]phenyl]propanamine

: 108-24-7
acetic anhydride

: 1222138-70-6
N-[3-[3-[5-[[1-(tert-butoxycarbonyl)-2(S)-azetidinyl]methoxy]-3-pyridyl]phenyl]propyl]acetamide

Guidance literature:: With triethylamine; dmap; In dichloromethane; at 0 ℃; Cooling with ice;

Reference yield:

: 186593-31-7
(S)-2-(5-bromo-pyridin-3-yloxymethyl)-azetidine-1-carboxylic acid tert-butyl ester

: 1222138-70-6
N-[3-[3-[5-[[1-(tert-butoxycarbonyl)-2(S)-azetidinyl]methoxy]-3-pyridyl]phenyl]propyl]acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 27 h / 90 °C / Inert atmosphere

2: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; cesium fluoride / water; N,N-dimethyl-formamide / 5 h / 50 °C / Inert atmosphere

3: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; water / 20 °C / Inert atmosphere

4: ethylenediamine / tetrahydrofuran; ethanol; acetonitrile / 2.67 h / 60 °C / Reflux

5: dmap; triethylamine / dichloromethane / 2.65 h / 0 °C / Inert atmosphere; Cooling with ice

With dmap; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ethylenediamine; triethylamine; triphenylphosphine; cesium fluoride; diethylazodicarboxylate; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 1222138-21-7
3-[3-[5-[[1-(tert-butoxycarbonyl)-2(S)-azetidinyl]methoxy]-3-pyridyl]phenyl]-1-propanol

: 1222138-70-6
N-[3-[3-[5-[[1-(tert-butoxycarbonyl)-2(S)-azetidinyl]methoxy]-3-pyridyl]phenyl]propyl]acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; water / 20 °C / Inert atmosphere

2: ethylenediamine / tetrahydrofuran; ethanol; acetonitrile / 2.67 h / 60 °C / Reflux

3: dmap; triethylamine / dichloromethane / 2.65 h / 0 °C / Inert atmosphere; Cooling with ice

With dmap; ethylenediamine; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile;