(S)-2-((1-fluorobut-3-en-2-yl)oxy)-1-(2-fluorophenyl)ethanone oxime

Base Information

• Chemical Name: (S)-2-((1-fluorobut-3-en-2-yl)oxy)-1-(2-fluorophenyl)ethanone oxime
• CAS No.: 1391001-90-3
• Molecular Formula: C₁₂H₁₃F₂NO₂
• Molecular Weight: 241.238
• Mol file: 1391001-90-3.mol

Synonyms:(S)-2-((1-fluorobut-3-en-2-yl)oxy)-1-(2-fluorophenyl)ethanone oxime

Chemical Property of (S)-2-((1-fluorobut-3-en-2-yl)oxy)-1-(2-fluorophenyl)ethanone oxime

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-((1-fluorobut-3-en-2-yl)oxy)-1-(2-fluorophenyl)ethanone oxime

There total 4 articles about (S)-2-((1-fluorobut-3-en-2-yl)oxy)-1-(2-fluorophenyl)ethanone oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-((1-fluorobut-3-en-2-yl)oxy)-1-(2-fluorophenyl)ethanone (1391001-89-0) → (S)-2-((1-fluorobut-3-en-2-yl)oxy)-1-(2-fluorophenyl)ethanone oxime (1391001-90-3)

Guidance literature:

With hydroxylamine hydrochloride; sodium acetate; In methanol; at 50 ℃; for 1.5h;

Reference yield:

tert-butyl (S)-2-((1-fluorobut-3-en-2-yl)oxy)acetate (1391001-87-8) → (S)-2-((1-fluorobut-3-en-2-yl)oxy)-1-(2-fluorophenyl)ethanone oxime (1391001-90-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: formic acid / 0 - 20 °C

2.1: 1,1'-carbonyldiimidazole / dichloromethane / 3 - 20 °C

2.2: 3 - 20 °C

3.1: n-butyllithium / hexane; tetrahydrofuran / -78 - -60 °C / Inert atmosphere

3.2: -78 - -60 °C

4.1: hydroxylamine hydrochloride; sodium acetate / methanol / 1.5 h / 50 °C

With n-butyllithium; formic acid; hydroxylamine hydrochloride; sodium acetate; 1,1'-carbonyldiimidazole; In tetrahydrofuran; methanol; hexane; dichloromethane;

Reference yield:

(S)-2-((1-fluorobut-3-en-2-yl)oxy)-N-methoxy-N-methylacetamide (1391001-88-9) → (S)-2-((1-fluorobut-3-en-2-yl)oxy)-1-(2-fluorophenyl)ethanone oxime (1391001-90-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / -78 - -60 °C / Inert atmosphere

1.2: -78 - -60 °C

2.1: hydroxylamine hydrochloride; sodium acetate / methanol / 1.5 h / 50 °C

With n-butyllithium; hydroxylamine hydrochloride; sodium acetate; In tetrahydrofuran; methanol; hexane;

upstream raw materials:

tert-butyl (S)-2-((1-fluorobut-3-en-2-yl)oxy)acetate

(S)-2-((1-fluorobut-3-en-2-yl)oxy)-N-methoxy-N-methylacetamide

(S)-2-((1-fluorobut-3-en-2-yl)oxy)-1-(2-fluorophenyl)ethanone

Downstream raw materials:

tert-butyl ((4aS,5S,7aS)-7a-(5-amino-2-fluorophenyl)-5-(fluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)carbamate

N-((4aS,5S,7aS)-5-(fluoromethyl)-7a-(2-fluorophenyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)benzamide

(4aS,5S,7aS)-5-(fluoromethyl)-7a-(2-fluorophenyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-amine

tert-butyl ((4aS,5S,7aS)-7a-(2-fluoro-5-nitrophenyl)-5-(fluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)carbamate