ethyl 2-(4-(4-(2-ethoxy-2-oxoethyl)phenyl)pyridin-2-yl)-2,2-difluoroacetate

Base Information

Chemical Name:ethyl 2-(4-(4-(2-ethoxy-2-oxoethyl)phenyl)pyridin-2-yl)-2,2-difluoroacetate
CAS No.:1243246-23-2
Molecular Formula:C₁₉H₁₉F₂NO₄
Molecular Weight:363.361
Hs Code.:

Synonyms:ethyl 2-(4-(4-(2-ethoxy-2-oxoethyl)phenyl)pyridin-2-yl)-2,2-difluoroacetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl 2-(4-(4-(2-ethoxy-2-oxoethyl)phenyl)pyridin-2-yl)-2,2-difluoroacetate

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Technology Process of ethyl 2-(4-(4-(2-ethoxy-2-oxoethyl)phenyl)pyridin-2-yl)-2,2-difluoroacetate

There total 1 articles about ethyl 2-(4-(4-(2-ethoxy-2-oxoethyl)phenyl)pyridin-2-yl)-2,2-difluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 667-27-6
Ethyl bromodifluoroacetate

: 1243246-22-1
ethyl 2-(4-(2-bromopyridin-4-yl)phenyl)acetate

: 1243246-23-2
ethyl 2-(4-(4-(2-ethoxy-2-oxoethyl)phenyl)pyridin-2-yl)-2,2-difluoroacetate

Guidance literature:: With copper; In N,N-dimethyl-formamide; at 80 ℃; for 1h; Inert atmosphere; Sealed tube;

Reference yield:

: 1243246-23-2
ethyl 2-(4-(4-(2-ethoxy-2-oxoethyl)phenyl)pyridin-2-yl)-2,2-difluoroacetate

: 1243246-24-3
2-(4-(2-(difluoromethyl)pyridin-4-yl)phenyl)acetic acid

Guidance literature:: ethyl 2-(4-(4-(2-ethoxy-2-oxoethyl)phenyl)pyridin-2-yl)-2,2-difluoroacetate; With water; lithium hydroxide; In methanol; at 55 ℃; for 12h;

With hydrogenchloride; In water; N,N-dimethyl-formamide; at 130 ℃; for 3h;