(E)-2-((1,4-dimethylpiperazin-2-ylidene)-amino)-5-nitro-N-phenylbenzamide

Base Information

• Chemical Name: (E)-2-((1,4-dimethylpiperazin-2-ylidene)-amino)-5-nitro-N-phenylbenzamide
• CAS No.: 1613465-33-0
• Molecular Formula: C₁₉H₂₁N₅O₃
• Molecular Weight: 367.407

Synonyms:(E)-2-((1,4-dimethylpiperazin-2-ylidene)-amino)-5-nitro-N-phenylbenzamide

Chemical Property of (E)-2-((1,4-dimethylpiperazin-2-ylidene)-amino)-5-nitro-N-phenylbenzamide

Chemical Property:

• Density: 1.29±0.1 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

ML336 ^*data from reagent suppliers

Safty Information:

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Technology Process of (E)-2-((1,4-dimethylpiperazin-2-ylidene)-amino)-5-nitro-N-phenylbenzamide

There total 7 articles about (E)-2-((1,4-dimethylpiperazin-2-ylidene)-amino)-5-nitro-N-phenylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

2-(chloromethyl)-6-nitro-3-phenylquinazolin-4(3H)-one (52692-81-6) + N,N`-dimethylethylenediamine (110-70-3) → (E)-2-((1,4-dimethylpiperazin-2-ylidene)-amino)-5-nitro-N-phenylbenzamide (1613465-33-0)

Guidance literature:

With potassium carbonate; In acetonitrile; at 50 ℃; for 2h;

DOI:10.1021/jm501203v

Reference yield: 49.0%

tert-butyl N-methyl (2-(methyl((6-nitro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)methyl)amino)ethyl)carbamate (1613465-77-2) → (E)-2-((1,4-dimethylpiperazin-2-ylidene)-amino)-5-nitro-N-phenylbenzamide (1613465-33-0)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.75h;

Reference yield:

2-amino-5-nitro-benzoic acid (616-79-5) → (E)-2-((1,4-dimethylpiperazin-2-ylidene)-amino)-5-nitro-N-phenylbenzamide (1613465-33-0)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

2: trichlorophosphate / acetonitrile / 0.25 h / 150 °C / Inert atmosphere; Microwave irradiation

3: potassium carbonate; potassium iodide / acetonitrile / 0.08 h / 80 °C / Microwave irradiation

4: trifluoroacetic acid / dichloromethane / 0.75 h / 20 °C

With potassium carbonate; triethylamine; trifluoroacetic acid; potassium iodide; trichlorophosphate; In dichloromethane; acetonitrile;

upstream raw materials:

tert-butyl N-methyl (2-(methyl((6-nitro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)methyl)amino)ethyl)carbamate

2-amino-5-nitro-benzoic acid

2-(chloromethyl)-6-nitro-4H-benzo[d][1,3]oxazin-4-one

2-(chloromethyl)-6-nitro-3-phenylquinazolin-4(3H)-one

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