4-nonafluorobutyl-2-oxo-6-phenyl-1,2-dihydro-pyridine-3-carbonitrile

Base Information

• Chemical Name: 4-nonafluorobutyl-2-oxo-6-phenyl-1,2-dihydro-pyridine-3-carbonitrile
• CAS No.: 417701-78-1
• Molecular Formula: C₁₆H₇F₉N₂O
• Molecular Weight: 414.23
• Mol file: 417701-78-1.mol

Synonyms:4-nonafluorobutyl-2-oxo-6-phenyl-1,2-dihydro-pyridine-3-carbonitrile

Chemical Property of 4-nonafluorobutyl-2-oxo-6-phenyl-1,2-dihydro-pyridine-3-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-nonafluorobutyl-2-oxo-6-phenyl-1,2-dihydro-pyridine-3-carbonitrile

There total 1 articles about 4-nonafluorobutyl-2-oxo-6-phenyl-1,2-dihydro-pyridine-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

cyanoacetic acid amide (107-91-5) + 4,4,5,5,6,6,7,7,7-nonafluoro-1-phenyl-heptane-1,3-dione (168920-97-6) → 4-nonafluorobutyl-2-oxo-6-phenyl-1,2-dihydro-pyridine-3-carbonitrile (417701-78-1)

Guidance literature:

With ammonium acetate; In ethanol; for 5h; Heating;

DOI:10.1023/A:1012455709358

Reference yield: 74.0%

4-nonafluorobutyl-2-oxo-6-phenyl-1,2-dihydro-pyridine-3-carbonitrile (417701-78-1) → 2-chloro-4-nonafluorobutyl-6-phenyl-nicotinonitrile (417701-83-8)

Guidance literature:

With trichlorophosphate; In N,N-dimethyl-formamide; for 8h; Heating;

DOI:10.1023/A:1012455709358

Reference yield:

4-nonafluorobutyl-2-oxo-6-phenyl-1,2-dihydro-pyridine-3-carbonitrile (417701-78-1) → 7-nonafluorobutyl-5-phenyl-2,3-dihydro-imidazo[1,2-a]pyridine-8-carbonitrile

Guidance literature:

Multi-step reaction with 3 steps

1: 74 percent / POCl₃ / dimethylformamide / 8 h / Heating

2: 66 percent / dioxane / 3 h / Heating

3: 87 percent / POCl₃ / 1 h / Heating

With trichlorophosphate; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1023/A:1012455709358

upstream raw materials:

cyanoacetic acid amide

4,4,5,5,6,6,7,7,7-nonafluoro-1-phenyl-heptane-1,3-dione

Downstream raw materials:

2-chloro-4-nonafluorobutyl-6-phenyl-nicotinonitrile

2-(2-hydroxy-ethylamino)-4-nonafluorobutyl-6-phenyl-nicotinonitrile