(S)-ethyl 3-((R)-3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl)-thiazolidine-2-carboxylate

Base Information

Chemical Name:(S)-ethyl 3-((R)-3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl)-thiazolidine-2-carboxylate
CAS No.:1041612-08-1
Molecular Formula:C₂₁H₂₇F₃N₂O₅S
Molecular Weight:476.517
Hs Code.:

Synonyms:(S)-ethyl 3-((R)-3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl)-thiazolidine-2-carboxylate

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Chemical Property of (S)-ethyl 3-((R)-3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl)-thiazolidine-2-carboxylate

Chemical Property:

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Technology Process of (S)-ethyl 3-((R)-3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl)-thiazolidine-2-carboxylate

There total 3 articles about (S)-ethyl 3-((R)-3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl)-thiazolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1041676-35-0
(S)-ethyl thiazolidine-2-carboxylate

: 486460-00-8,922178-94-7
(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

: 1041612-08-1
(S)-ethyl 3-((R)-3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl)-thiazolidine-2-carboxylate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 12h;

Reference yield:

: 1041676-37-2
(S)-ethyl thiazolidine-2-carboxylate L-tartaric acid salt

: 1041612-08-1
(S)-ethyl 3-((R)-3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl)-thiazolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / diethyl ether; water / 0.5 h / 10 °C

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 12 h / 20 °C

With dmap; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In diethyl ether; dichloromethane; water;
DOI:10.1016/j.bmcl.2011.01.041

Reference yield:

: 33305-10-1,65126-73-0,65126-75-2
ethyl thiazolidine-2-carboxylate

: 1041612-08-1
(S)-ethyl 3-((R)-3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl)-thiazolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / 120 h / 20 - 40 °C

2: sodium hydrogencarbonate / diethyl ether; water / 0.5 h / 10 °C

3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 12 h / 20 °C

With dmap; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In diethyl ether; ethanol; dichloromethane; water;
DOI:10.1016/j.bmcl.2011.01.041