(3R,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid

Base Information

Chemical Name:(3R,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid
CAS No.:72155-51-2
Molecular Formula:C11H15 N O3
Molecular Weight:209.24
Hs Code.:
DSSTox Substance ID:DTXSID20992877
Nikkaji Number:J1.585.224K
Mol file:72155-51-2.mol

Synonyms:4-AHPPA;4-amino-3-hydroxy-5-phenylpentanoic acid;4-amino-3-hydroxy-5-phenylpentanoic acid, (S-(R*,R*))-isomer

Suppliers and Price of (3R,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 8 raw suppliers

Chemical Property of (3R,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid

Chemical Property:

Vapor Pressure:5.85E-09mmHg at 25°C
Boiling Point:452°C at 760 mmHg
PKA:3.94±0.10(Predicted)
Flash Point:227.2°C
PSA：83.55000
Density:1.243g/cm³
LogP:1.09230
XLogP3:-2.1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:209.10519334
Heavy Atom Count:15
Complexity:202

Purity/Quality:: 98%Min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)CC(C(CC(=O)O)O)N
Isomeric SMILES:C1=CC=C(C=C1)C[C@@H]([C@@H](CC(=O)O)O)N

Technology Process of (3R,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid

There total 8 articles about (3R,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 390377-68-1
(3R,4S)-4-(N,N-dibenzylamino)-3-hydroxy-5-phenylpentanoic acid

: 72155-51-2,153061-61-1
(3R,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid

Guidance literature:: With hydrogen; palladium hydroxide - carbon; In methanol; water; for 26h;
DOI:10.1016/S0040-4020(01)00804-3

Reference yield: 86.0%

: 390377-29-4
tert-butyl (3R,4S)-4-(N,N-dibenzylamino)-3-hydroxy-5-phenylpentanoate

: 72155-51-2,153061-61-1
(3R,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid

Guidance literature:: tert-butyl (3R,4S)-4-(N,N-dibenzylamino)-3-hydroxy-5-phenylpentanoate; With trifluoroacetic acid; In dichloromethane;

With palladium on activated charcoal; hydrogen; In methanol;
DOI:10.1039/c5ra20976e

Reference yield:

: 123054-12-6,123808-74-2,136370-73-5,111060-64-1
(2S)-N,N-dibenzylphenylalaninal

: 72155-51-2,153061-61-1
(3R,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 52 percent / tetrahydrofuran / 1.5 h / 0 °C

2: 85 percent / trifluoroacetic acid / 4 h / 20 °C

3: 97 percent / H₂ / 20 percent Pd(OH)2-C / methanol; H₂O / 26 h

With hydrogen; trifluoroacetic acid; palladium hydroxide - carbon; In tetrahydrofuran; methanol; water; 1: Reformatsky reaction;
DOI:10.1016/S0040-4020(01)00804-3