5-cyclohex-1-enyl-3-[(trans-4-hydroxy-cyclohexyl)-(4-trans-methyl-cyclohexanecarbonyl)-amino]-thiophene-2-carboxylic acid

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Chemical Name:5-cyclohex-1-enyl-3-[(trans-4-hydroxy-cyclohexyl)-(4-trans-methyl-cyclohexanecarbonyl)-amino]-thiophene-2-carboxylic acid
CAS No.:914778-81-7
Molecular Formula:C₂₅H₃₅NO₄S
Molecular Weight:445.623
Hs Code.:

Synonyms:5-cyclohex-1-enyl-3-[(trans-4-hydroxy-cyclohexyl)-(4-trans-methyl-cyclohexanecarbonyl)-amino]-thiophene-2-carboxylic acid

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Chemical Property of 5-cyclohex-1-enyl-3-[(trans-4-hydroxy-cyclohexyl)-(4-trans-methyl-cyclohexanecarbonyl)-amino]-thiophene-2-carboxylic acid

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Technology Process of 5-cyclohex-1-enyl-3-[(trans-4-hydroxy-cyclohexyl)-(4-trans-methyl-cyclohexanecarbonyl)-amino]-thiophene-2-carboxylic acid

There total 2 articles about 5-cyclohex-1-enyl-3-[(trans-4-hydroxy-cyclohexyl)-(4-trans-methyl-cyclohexanecarbonyl)-amino]-thiophene-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 914781-01-4
lithium 5-bromo-3-[(trans-4-hydroxy-cyclohexyl)-(trans-4-methylcyclohexanecarbonyl)-amino]-thiophene-2-carboxylate

: 89490-05-1,21190-87-4
cyclohex-1-enylboronic acid

: 914778-81-7
5-cyclohex-1-enyl-3-[(trans-4-hydroxy-cyclohexyl)-(4-trans-methyl-cyclohexanecarbonyl)-amino]-thiophene-2-carboxylic acid

Guidance literature:: lithium 5-bromo-3-[(trans-4-hydroxy-cyclohexyl)-(trans-4-methylcyclohexanecarbonyl)-amino]-thiophene-2-carboxylate; cyclohex-1-enylboronic acid; With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; for 0.25h; Heating / reflux;

With hydrogenchloride; In water; pH=4;

Reference yield:

: 914780-77-1
5-cyclohex-2-enyl-3-[(trans-4-hydroxy-cyclohexyl)-(trans-4-methyl-cyclohexanecarbonyl)-amino]-thiophene-2-carboxylic acid methyl ester

: 914780-16-8
5-cyclohex-2-enyl-3-[(trans-4-hydroxy-cyclohexyl)-(trans-4-methyl-cyclohexanecarbonyl)-amino]-thiophene-2-carboxylic acid

: 914778-81-7
5-cyclohex-1-enyl-3-[(trans-4-hydroxy-cyclohexyl)-(4-trans-methyl-cyclohexanecarbonyl)-amino]-thiophene-2-carboxylic acid

Guidance literature:: 5-cyclohex-2-enyl-3-[(trans-4-hydroxy-cyclohexyl)-(trans-4-methyl-cyclohexanecarbonyl)-amino]-thiophene-2-carboxylic acid methyl ester; With lithium hydroxide; water; In tetrahydrofuran; methanol; at 50 ℃; for 4.5h;

With hydrogenchloride; In water; ethyl acetate;

Reference yield: 45.0%

: 914778-81-7
5-cyclohex-1-enyl-3-[(trans-4-hydroxy-cyclohexyl)-(4-trans-methyl-cyclohexanecarbonyl)-amino]-thiophene-2-carboxylic acid

: 30293-86-8
methyl (S)-(-)-2-isocyanato-3-methylbutyrate

: C₃₂H₄₆N₂O₇S

Guidance literature:: 5-cyclohex-1-enyl-3-[(trans-4-hydroxy-cyclohexyl)-(4-trans-methyl-cyclohexanecarbonyl)-amino]-thiophene-2-carboxylic acid; methyl (S)-(-)-2-isocyanato-3-methylbutyrate; In toluene; at 70 ℃; for 2h;

With water; In toluene; at 20 ℃; for 1h;