2-{(Z)-2-bromo-3-{N-[(1R)-1-(cyclohexyl)hept-2-ynyl]-N-[(4-methylphenylsulfonyl)amino]}prop-1-enyl}-N,N-dimethyl-1H-pyrrole-1-sulfonamide

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Chemical Name:2-{(Z)-2-bromo-3-{N-[(1R)-1-(cyclohexyl)hept-2-ynyl]-N-[(4-methylphenylsulfonyl)amino]}prop-1-enyl}-N,N-dimethyl-1H-pyrrole-1-sulfonamide
CAS No.:1342340-98-0
Molecular Formula:C₂₉H₄₀BrN₃O₄S₂
Molecular Weight:638.69
Hs Code.:

Synonyms:2-{(Z)-2-bromo-3-{N-[(1R)-1-(cyclohexyl)hept-2-ynyl]-N-[(4-methylphenylsulfonyl)amino]}prop-1-enyl}-N,N-dimethyl-1H-pyrrole-1-sulfonamide

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Chemical Property of 2-{(Z)-2-bromo-3-{N-[(1R)-1-(cyclohexyl)hept-2-ynyl]-N-[(4-methylphenylsulfonyl)amino]}prop-1-enyl}-N,N-dimethyl-1H-pyrrole-1-sulfonamide

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Technology Process of 2-{(Z)-2-bromo-3-{N-[(1R)-1-(cyclohexyl)hept-2-ynyl]-N-[(4-methylphenylsulfonyl)amino]}prop-1-enyl}-N,N-dimethyl-1H-pyrrole-1-sulfonamide

There total 8 articles about 2-{(Z)-2-bromo-3-{N-[(1R)-1-(cyclohexyl)hept-2-ynyl]-N-[(4-methylphenylsulfonyl)amino]}prop-1-enyl}-N,N-dimethyl-1H-pyrrole-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: N-[(1R)-1-cyclohexylhept-2-ynyl]-4-methylbenzenesulfonamide

: 1342341-41-6
2-[(Z)-2-bromo-3-hydroxyprop-1-enyl]-N,N-dimethyl-1H-pyrrole-1-sulfonamide

: 1342340-98-0
2-{(Z)-2-bromo-3-{N-[(1R)-1-(cyclohexyl)hept-2-ynyl]-N-[(4-methylphenylsulfonyl)amino]}prop-1-enyl}-N,N-dimethyl-1H-pyrrole-1-sulfonamide

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; toluene; at 0 - 20 ℃;
DOI:10.1055/s-0030-1260098

Reference yield:

: 1003-29-8,254729-95-8
2-pyrrole aldehyde

: 1342340-98-0
2-{(Z)-2-bromo-3-{N-[(1R)-1-(cyclohexyl)hept-2-ynyl]-N-[(4-methylphenylsulfonyl)amino]}prop-1-enyl}-N,N-dimethyl-1H-pyrrole-1-sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: chloroform / 12 h / Reflux

2.1: sodium hydride / tetrahydrofuran; mineral oil / Cooling

2.2: 15 h / Cooling

3.1: diisobutylaluminium hydride / tetrahydrofuran; hexane / 3 h / Cooling

4.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran; toluene / 0 - 20 °C

With di-isopropyl azodicarboxylate; sodium hydride; diisobutylaluminium hydride; triphenylphosphine; In tetrahydrofuran; hexane; chloroform; toluene; mineral oil;
DOI:10.1055/s-0030-1260098

Reference yield:

: 1342341-40-5
methyl (Z)-2-bromo-3-[1-(dimethylaminosulfonyl)-1H-pyrrol-2-yl]prop-2-enoate

: 1342340-98-0
2-{(Z)-2-bromo-3-{N-[(1R)-1-(cyclohexyl)hept-2-ynyl]-N-[(4-methylphenylsulfonyl)amino]}prop-1-enyl}-N,N-dimethyl-1H-pyrrole-1-sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: diisobutylaluminium hydride / tetrahydrofuran; hexane / 3 h / Cooling

2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran; toluene / 0 - 20 °C

With di-isopropyl azodicarboxylate; diisobutylaluminium hydride; triphenylphosphine; In tetrahydrofuran; hexane; toluene;
DOI:10.1055/s-0030-1260098